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首页> 外文期刊>The Australasian journal of dermatology >Trends in the incidence of Merkel cell carcinoma in Victoria, Australia, between 1986 and 2016
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Trends in the incidence of Merkel cell carcinoma in Victoria, Australia, between 1986 and 2016

机译：1986年至2016年间维多利亚Merkel细胞癌发生率的趋势

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Abstract Background/Objectives Merkel cell carcinoma ( MCC ) is a highly invasive cutaneous malignancy. The objective of this study was to investigate the incidence and trends of MCC in Victoria, Australia, between 1986 and 2016. Methods Population‐based, descriptive analysis of Victorian Cancer Registry ( VCR ) data. The de‐identified records of patients with MCC were obtained from Victoria residents diagnosed between 1986 and 2016. Trends in age‐standardised incidences were examined using joinpoint analysis. Results A total of 1095 cases were found. Incidence of MCC was 3.9 per 100?000 for men and 1.5 per 100?000 for women. The incidence of MCC in men 66–85 is increasing at an annual rate of 4.2% (2.8–5.8%, 95% CI ). However, since 2002 the incidence in women in the same age group has been decreasing. Whilst there is an overall stabilisation in the incidence of MCC , incidence of MCC for males is increasing. For MCC in males 85?years old and over, the incidence of MCC was 26.8 per 100?000 between 2012 and 2016. Relative 5‐year survival for patients diagnosed between 2008 and 2012 is 50%. Conclusion Merkel cell carcinoma remains an aggressive cancer, especially among older men. Differences in trends seen in local data can help target preventative and early intervention management strategies in specific groups.
机译：摘要背景/目标Merkel细胞癌（MCC）是一种高度侵入的皮肤恶性恶性肿瘤。本研究的目的是调查维多利亚州维多利亚MCC的发病率和趋势，于1986年至2016年期间。方法基于人口，对维多利亚时代的癌症注册表（VCR）数据的描述性分析。从1986年至2016年间诊断的维多利亚居民获得了MCC患者的去鉴定记录。使用JOINPOITION分析检查年龄标准化发病率的趋势。结果共有1095例。男性的MCC发病率为每100 000，每100 000为1.5 000为妇女。 MYC 66-85中MCC的发病率为每年增加4.2％（2.8-5.8％，95％CI）。但是，自2002年以来，同一年龄组妇女的发病率一直在下降。虽然MCC发病率存在整体稳定性，但雄性MCC的发病率正在增加。对于MOLES 85的MCC？历史悠久，MCC的发病率为2012年和2016年间每100 000 000。2008年至2012年诊断的患者的相对5年生存率为50％。结论Merkel细胞癌仍然是一种激进的癌症，尤其是老年人。本地数据中看到的趋势的差异可以帮助特定群体中的目标预防和早期干预管理策略。

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