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首页> 外文期刊>The Australasian journal of dermatology >A prospective diagnostic study on povidone-iodine retention in lesions suspected to be squamous cell carcinoma or keratoacanthoma
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A prospective diagnostic study on povidone-iodine retention in lesions suspected to be squamous cell carcinoma or keratoacanthoma

机译：具有鳞状细胞癌或角膜囊瘤的病变中POVIDONE-碘保留的前瞻性诊断研究

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Background and objectives While dermatoscopy improves diagnostic accuracy for raised nonpigmented lesions, those with white surface keratin can be problematical. We investigated whether retention of povidone-iodine by surface keratin provides a clue to benignity. Methods We performed a retrospective pilot study (n = 57) followed by a prospective study (n = 117) on raised nonpigmented lesions with white surface keratin. An initial dermatoscopic image was taken of each lesion, povidone-iodine was applied and another image taken. Following lavage with 70% ethanol, a third image was acquired. The percentage surface area of residual povidone-iodine staining after lavage was recorded, and the results analysed. Results The optimal cut-off point of residual staining was 80%, where values of = 80% pointed to malignancy. At this cut-off, the OR for lesions with values = 80% to be truly malignant in the retrospective set was 4.03 (95% CI: 2.1-7.6) and the AUC was 0.7 (95% CI: 0.62-0.78). For the prospective set, the corresponding OR was 2.3 (95% CI: 1.4-3.7) and the AUC was 0.62 (95% CI: 0.55-0.68). Conclusions This study presents evidence that povidone-iodine retention may have a degree of efficacy in distinguishing benign from malignant keratotic lesions. Further study is warranted.
机译：背景和目标，而Dermaticopy改善升高的非透明病变的诊断精度，那些具有白色表面角蛋白的人可能是有问题的。我们调查了表面角蛋白的Povidone-碘的保留是否为良性提供了线索。方法我们进行了回顾性试验研究（n = 57），然后进行了预期研究（n = 117），凸起的非斑点病变与白表面角蛋白。采用初始皮肤镜图像，每种病变，施用PoVidone-碘，并拍摄另一个图像。在用70％乙醇灌洗后，获得第三种图像。记录灌洗后残留的PoVidone-碘染色的百分比表面积，并分析结果。结果残余染色的最佳截止点为80％，其中＆ = 80％指向恶性肿瘤。在这种截止的情况下，具有值的病变或具有值的病变是真正恶性的回顾套装为4.03（95％CI：2.1-7.6），AUC为0.7（95％CI：0.62-0.78） 。对于前瞻性组，相应的或2.3（95％CI：1.4-3.7）和AUC为0.62（95％CI：0.55-0.68）。结论本研究表明POVIDONE-碘保留可能具有在区分良性角质病变中的疗效程度。进一步研究是有保证的。

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