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首页> 外文期刊>The Australasian journal of dermatology >Hidradenitis suppurativa and polycystic ovarian syndrome: Systematic review and meta‐analysis
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Hidradenitis suppurativa and polycystic ovarian syndrome: Systematic review and meta‐analysis

机译：Hidradenitisupturativa和多囊卵巢综合征：系统评论和荟萃分析

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Abstract Background/Objectives Hidradenitis suppurativa has been associated with a number of pathologies, including various endocrine and autoimmune disorders. Although signs of hyperandrogenism are common in hidradenitis suppurativa, few formal studies have assessed the relationship between hidradenitis suppurativa and polycystic ovarian syndrome. Therefore, we performed a systematic review and meta‐analysis to assess the association between hidradenitis suppurativa and polycystic ovarian syndrome. Methods We performed a systematic review and meta‐analysis according to PRISMA guidelines. Odds ratio was used as the effect size, with random‐effects meta‐analysis. Results We identified five case‐control studies for inclusion. From pooled data, we found a significantly higher proportion of polycystic ovarian syndrome in hidradenitis suppurativa cases compared with controls ( OR 2.64; 95% CI 1.69–4.11; P ??0.00001). There was significant heterogeneity noted ( I 2 ?=?88%, P ??0.00001). Limitations included that studies reviewed were observational by design which are susceptible to bias, and lack of randomisation. Conclusions In summary, pooled analysis of existing case‐control studies supports a significant association between hidradenitis suppurativa and polycystic ovarian syndrome. Our results imply that hidradenitis suppurativa patients with signs of hyperandrogenism may benefit from screening for polycystic ovarian syndrome, and may potentially benefit from anti‐androgen therapy.
机译：摘要背景/目标Hidradenitisupturativa已与许多病程相关联，包括各种内分泌和自身免疫疾病。虽然Hiatradenita isupurativa的迹象常见，但很少有正式研究评估了Hidradenitisupturativa和多囊卵巢综合征之间的关系。因此，我们进行了系统审查和荟萃分析，以评估Hidradenitisupturativa和多囊卵巢综合征之间的关联。方法根据Prisma指南，我们进行了系统审查和荟萃分析。使用差距为效果大小，随机效应元分析。结果我们确定了五个案例对照研究。从汇集数据中，我们发现与对照（或2.64; 95％CI 1.69-4.11;P≥10.00001）相比，我们发现Hidradenitisupsucativa病例中的多囊卵巢综合征比例显着更高比例。注意到了显着的异质性（I 2？=α= 88％，p≤≤0.000000）。包括易受偏见的设计审查的研究，审查的研究是观察到的，缺乏随机化。总结结论，汇总分析现有病例对照研究支持Hidradenita Suppurativa和多囊卵巢综合征之间的重大关联。我们的结果意味着Hiatradenita患者具有高衰老症迹象的患者可能会受益于对多囊卵巢综合征的筛选，并且可能从抗雄激素治疗中受益。

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