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首页> 外文期刊>The Australasian journal of dermatology >Association between bullous pemphigoid and psoriasis: Systematic review and meta-analysis of case-control studies
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Association between bullous pemphigoid and psoriasis: Systematic review and meta-analysis of case-control studies

机译：大疱性毒性和牛皮癣之间的关联：系统评论和案例控制研究的荟萃分析

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Several case reports and cohort studies have recently investigated the potential association between bullous pemphigoid (BP) and psoriasis. It has been speculated that chronic inflammation in the dermo-epidermal junction can trigger exposure to antigens to autoreactive T cells, resulting in autoimmune blistering disease. However, the association described has been inconsistently reported amongst studies. We performed a systematic review and meta-analysis to investigation this potential association. We identified four case-control studies for inclusion in the present meta-analysis, with a total of 4035 bullous pemphigoid cases and 19 215 control cases. There was a significantly higher prevalence of psoriasis in BP compared to controls (2.6% vs 1.1%, OR 2.5, 95% CI 1.4-4.6). Subgroup analysis showed that this association remained significant in both males (3.0% vs 1.3%, OR 2.4, 95% CI 1.6-3.6) as well as females (1.9% vs 0.7%, OR 2.9, 95% CI 1.4-5.9). A significantly higher proportion of cases were reported in males (3.0% vs 1.9%, OR 1.75, 95% CI 1.1-2.7). This pooled analysis of existing case-control studies to date demonstrates a significant association between BP and psoriasis. We also showed that in contrast with the majority of autoimmune diseases which are predisposed in females, that the coexistence of BP and psoriasis appears to be predisposed in male patients.
机译：最近有几种案例报告和队列研究已经调查了大疱性毒性（BP）和牛皮癣之间的潜在关联。已经推测，Dermo-表皮结中的慢性炎症可以引发暴露于抗原的自身反应性T细胞，导致自身免疫性起泡疾病。然而，所描述的协会在研究中已经不一致地报告。我们对调查这一潜在协会进行了系统审查和荟萃分析。我们确定了四种案例对照研究，用于纳入目前的荟萃分析，共有4035例大疱的猪病壳和1915例控制病例。与对照相比，BP的牛皮癣患有显着更高的牛皮癣（2.6％vs 1.1％，或2.5,95％CI 1.4-4.6）。亚组分析表明，这种关联在雄性中存在显着（3.0％vs 1.3％，2.4,95％CI 1.6-3.6）以及女性（1.9％vs 0.7％，或2.9,95％CI 1.4-5.9）。雄性中报告了显着更高的病例（3.0％vs 1.9％，或1.75,95％CI 1.1-2.7）。对迄今为止的现有病例对照研究的这种汇总分析证明了BP和牛皮癣之间的重要关联。我们还表明，与女性倾省的大多数自身免疫性疾病相比，BP和牛皮癣的共存似乎在男性患者中倾向于。

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