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首页> 外文期刊>The Australasian journal of dermatology >A prospective observational study of pigmented naevi changes in psoriasis patients on biologic therapy
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A prospective observational study of pigmented naevi changes in psoriasis patients on biologic therapy

机译：生物治疗牛皮癣患者色素瘤变化预期观察研究

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Background/Objectives Patients on biologic therapy are thought to be at increased risk of developing non-melanoma skin cancers and melanomas. It is unknown whether biologic therapy alters the natural history of melanocytic naevi. Therefore, a prospective observational study was conducted to determine whether psoriasis patients on biologic therapy develop changes in naevi. Methods Clinical and dermoscopic assessment of all melanocytic naevi was performed in 45 psoriasis patients on biologic therapy versus a control cohort of 43 subjects, using sequential digital dermoscopic imaging and total body photography. The mean follow-up period was 1.5 years. Results The study and control patients had comparable age, gender, previous and family history of non-melanoma skin cancers and melanomas, as well as previous sun exposure and total number of naevi. The number of naevi with major dermoscopic changes was 3% in the study and 1.9% in the control group, with an adjusted incidence rate ratio of 1.45 (95% confidence interval 0.90-2.33; P = 0.125). The rate of minor changes was 15.9% in the study group versus 19.4% in the control (adjusted incidence rate ratio 0.77, 95% confidence interval 0.57-1.08; P = 0.14). There were six new dysplastic naevi in 4/45 biologic patients and four in 4/43 controls; however, the difference was not significant (relative risk 0.96, 95% confidence interval -0.12 to 0.12; P = 0.95). There were no melanomas in either group. Conclusion Over a mean follow-up period of 1.5 years there was no evidence of significantly different changes in naevi or development of new dysplastic naevi in psoriasis patients on biologic treatment compared to controls.
机译：背景/目标生物疗法患者被认为是发展非黑色素瘤皮肤癌和黑色素的风险增加。它尚不清楚生物学治疗是否改变了黑素细胞Naevi的自然病史。因此，进行了预期观察研究以确定生物治疗牛皮癣患者是否在Naevi发生变化。方法对45例牛皮癣患者进行临床和皮肤病评估，在45例生物治疗患者中进行，与43个受试者的对照队列，使用顺序数字DERMISCOPIC成像和全身摄影。平均随访时间为1.5岁。结果研究和对照患者具有可比年龄，性别，前一种和非黑色素瘤皮肤癌和黑色素的家族史以及以前的阳光照射和Naevi的总数。在研究中具有主要的Dermospopic变化的Naevi的数量为3％，对照组中1.9％，调节发射率为1.45（95％置信区间0.90-2.33; P = 0.125）。研究组的轻微变化率为15.9％，对照组（调整后发病率比0.77，95％置信区间0.57-1.08; p = 0.14）。 4/45生物学患者中有六种新的发育性Naevi，4/43控制中有四个;然而，差异不显着（相对风险为0.96,95％置信区间-0.12至0.12; p = 0.95）。两组中没有黑色素瘤。结论在平均后续期间为1.5年，没有证据表明Naevi与对照组的生物治疗患者新发狂Naevi的显着不同变化。

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