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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >A systematic review of factors that influence the efficacy of cognitive remediation therapy in schizophrenia
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A systematic review of factors that influence the efficacy of cognitive remediation therapy in schizophrenia

机译：对影响认知修复治疗在精神分裂症中的疗效的因素的系统综述

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Objective: Cognitive remediation therapy is a moderately effective intervention for ameliorating cognitive deficits in individuals with schizophrenia-related disorders. With reports of considerable variability in individual response to cognitive remediation therapy, we need to better understand factors that influence cognitive remediation therapy efficacy to realise its potential. A systematic review was conducted to identify and evaluate predictors of cognitive outcome. Methods: An electronic database search was conducted identifying peer-reviewed articles examining predictors of cognitive response to cognitive remediation therapy. Results: A total of 40 articles accounting for 1681 cognitive remediation therapy participants were included; 81 distinct predictors of cognitive response were identified. Data synthesis and discussion focused on 20 predictors examined a minimum three times in different studies. Few of the examined predictors of cognitive outcome following cognitive remediation therapy were significant when examined through systematic review. A strong trend was found for baseline cognition, with reasoning and problem solving and working memory being strongly predictive of within-domain improvement. Training task progress was the most notable cross-domain predictor of cognitive outcome. Conclusion: It remains unclear why a large proportion of participants fail to realise cognitive benefit from cognitive remediation therapy. However, when considering only those variables where a majority of articles reported a statistically significant association with cognitive response to cognitive remediation therapy, three stand out: premorbid IQ, baseline cognition and training task progress. Each of these relates in some way to an individual's capacity or potential for change. There is a need to consolidate investigation of potential predictors of response to cognitive remediation therapy, strengthening the evidence base through replication and collaboration.
机译：目的：认知修复治疗是一种适度有效的干预，用于改善具有精神分裂症相关疾病的个体的认知缺陷。随着个人反应对认知修复治疗的相当变异的报道，我们需要更好地了解影响认知修复治疗效果以实现其潜力的因素。进行了系统审查，以确定和评估认知结果的预测因子。方法：进行电子数据库搜索，识别对同行评审的文章检查对认知补救疗法的认知反应预测因子。结果：共有40篇文章占1681年认知修复治疗参与者的物品;确定了认知反应的不同预测因子。专注于20个预测因子的数据综合和讨论在不同的研究中检查了至少三次。在通过系统审查中检查时，在认知修复治疗后的认知结果的研究预测因子很少。为基线认知发现了强大的趋势，推理和问题解决和工作记忆力强烈预测域内改善。培训任务进度是认知结果最值得注意的跨域预测因子。结论：尚不清楚为什么大部分参与者无法实现认知修复治疗的认知益处。然而，在考虑大多数文章报告与认知补救疗法的认知反应统计上显着联系的那些变量时，三次突出：前置前瞻性智商，基线认知和培训任务进展。这些中的每一个都以某种方式与个人的能力或变革的潜力相关联。有必要巩固对应对认知修复治疗的潜在预测因子的调查，通过复制和协作加强证据基础。

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