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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >The impact of depression heterogeneity on cognitive control in major depressive disorder.
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The impact of depression heterogeneity on cognitive control in major depressive disorder.

机译：抑郁症异质性对重大抑郁症认知控制的影响。

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Depressed patients display a variety of deficits in neuropsychological function, and contradictory findings in the literature may be due to disorder heterogeneity. The aim of this study was to examine the impact of severity, subtype and symptoms on cognitive control.Neuropsychological function across a range of cognitive control tasks was examined in melancholic (n = 65) and non-melancholic depressed patients (n = 59) relative to controls (n = 124). The relationship between subtype (melancholia vs non-melancholia) and anxiety was also examined.Melancholia was characterised by attention and working memory deficits typically associated with the dorsolateral prefrontal cortex, while non-melancholia was characterised by verbal memory recall deficits indicative of left frontal lobe and medial temporal lobe function. The severity of anxious arousal and psychomotor disturbance contributed to cognitive impairment more than the severity of depression symptoms and anxious apprehension.Findings highlight a differential impact of depression subtype and severity, and suggest that anxious arousal and psychomotor disturbance may contribute to poorer performance on neuropsychological tasks associated with dorsolateral prefrontal cortex function.
机译：抑郁症患者在神经心理功能中显示各种缺陷，文献中的矛盾发现可能是由于疾病异质性。本研究的目的是检查严重程度，亚型和症状对认知控制的影响。在忧郁（n = 65）和非忧郁抑郁症患者（n = 59）相对中检查了一系列认知控制任务的血糖心理功能。相对控制（n = 124）。还检查了亚​​型（Melancholia VS非忧郁症）和焦虑之间的关系。目的是通过注意力和工作记忆缺陷的特征在于，通常与背侧前额叶皮质相关，而非忧郁的记忆召回指示左前叶的缺陷的特征和中间颞叶功能。焦虑的令人焦虑和精神障碍的严重程度导致认知障碍超过抑郁症状和焦虑的严重程度。挑战突出了抑郁症亚型和严重程度的差异影响，并表明焦虑令人焦虑和精神障碍可能导致神经心理任务的表现较差与背侧前额外皮层函数相关。

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