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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Colorectal, cervical and prostate cancer screening in Australians with severe mental illness: Retrospective nation-wide cohort study
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Colorectal, cervical and prostate cancer screening in Australians with severe mental illness: Retrospective nation-wide cohort study

机译：澳大利亚人患有严重精神疾病的结肠直肠，宫颈癌和前列腺癌筛查：回顾性国家范围的队列研究

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Objective: People with severe mental illness have similar cancer incidence, but higher mortality than the general population. Participation in cancer screening may be a contributing factor but existing studies are conflicting. The aim of this study was to investigate the frequency of colorectal, prostate and cervical cancer screening among people with and without severe mental illness in Australia, who have access to universal health care. Methods: We followed three cohorts using de-identified data from a random 10% sample of people registered for Australia's universal health care system: those aged 50-69 years (n = 760,058) for colorectal cancer screening; women aged 18-69 years (n = 918,140) for cervical cancer screening and men aged 50-69 years (n = 380,238) for prostate cancer screening. We used Poisson regression to estimate incidence rate ratios and 95% confidence intervals for the association between severe mental illness and rates of faecal occult blood testing, pap smears and prostate-specific antigen testing. Results: Having severe mental illness was associated with a 17% reduction in rates of pap smear (incidence rate ratio = 0.83, 95% confidence interval: 0.82-0.84) and prostate-specific antigen testing (incidence rate ratio = 0.83, 95% confidence interval: 0.81-0.85), compared to the general population. By contrast, incidence rates of faecal occult blood testing were only lower in people with severe mental illness among the participants who visited their general practitioner less than an average of five times per year (incidence rate ratio = 0.83, 95% confidence interval = [0.73, 0.94]). Conclusion: Our results suggest that differences in screening frequency may explain some of the mismatch between cancer incidence and mortality in people with severe mental illness and indicate that action is required to improve preventive screening in this very disadvantaged group.
机译：目的：严重精神疾病的人具有相似的癌症发病率，但死亡率高于一般人群。参与癌症筛查可能是贡献因素，但现有的研究是矛盾的。本研究的目的是探讨澳大利亚患有和没有严重精神疾病的人的结肠直肠，前列腺和宫颈癌筛查的频率，他们可以获得普遍保健。方法：我们遵循三个队列，使用除澳大利亚全球医疗保健系统注册的随机10％人员样本的De-Identified数据：年龄50-69岁（n = 760,058）的结直肠癌筛查;宫颈癌筛查和50-69岁（N = 380,238岁）的前列腺癌筛查，女性为18-69岁（n = 918,140）。我们使用Poisson回归来估算发病率比和95％的置信区间隔，对严重精神疾病和粪便潜血试验，PAP涂片和前列腺特异性抗原检测的急性。结果：严重的精神疾病与PAP涂抹率降低17％（发病率比率= 0.83，95％置信区间：0.82-0.84）和前列腺特异性抗原检测（发病率比率= 0.83，95％的信心）相关间隔：0.81-0.85），与一般人群相比。相比之下，粪便隐匿性血液检测的发病率仅较严重的精神疾病的人群，参与者每年持续低于平均五次（发病率比率= 0.83，95％置信区间= [0.73） ，0.94]）。结论：我们的研究结果表明，筛查频率的差异可以解释癌症发病率和患有严重精神疾病的人们的死亡率的一些不匹配，并表明需要采取行动来改善这一非常弱势群体中的预防筛查。

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