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Clozapine rechallenge following QTc prolongation

机译:曲氮平重新检查QTC延长后

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摘要

We read with interest Nielsen's response (Nielsen, 2012) to our case study published in 2011 regarding QTc prolongation in a patient (Ms A) treated with clozapine (Dhillon et al., 2011). Nielsen raised several issues that need to be factored in before discontinuing clozapine due to prolonged QTc, which included: using Fridericia's formula rather than Bazett's formula for calculating the QTc interval (as it better corrects for heart rates greater than 70 beats per minute), using manual readings rather than machine readings and analysing the QT interval in conjunction with clozapine plasma levels.
机译:我们用兴趣介绍了Nielsen的回应(Nielsen,2012),我们的案例研究于2011年发表了关于用氯氮平治疗的患者(MS A)的QTC延长(Dhillon等,2011)。 尼尔森在停止克罗茨加之前提出了几个需要考虑的问题,这包括:使用Fridericia的配方而不是Bazett的公式来计算QTC间隔(因为它更好地纠正了每分钟大于70次的心率),使用 手动读数而不是机器读数,并与氯氮平等离子体水平结合分析QT间隔。

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    Discipline of Psychiatry University of Tasmania Hobart Australia;

    Queen Elizabeth Hospital 28 Woodville Road Woodville-South-Adelaide-SA-5011 Australia;

    Department of Psychiatry Royal Hobart Hospital Hobart Australia;

    Queen Elizabeth Hospital 28 Woodville Road Woodville-South-Adelaide-SA-5011 Australia;

    Flinders University Bedford Park Adelaide Australia;

    Queen Elizabeth Hospital 28 Woodville Road Woodville-South-Adelaide-SA-5011 Australia;

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  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
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