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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Intrinsic brain abnormalities in young healthy adults with childhood trauma: A resting-state functional magnetic resonance imaging study of regional homogeneity and functional connectivity
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Intrinsic brain abnormalities in young healthy adults with childhood trauma: A resting-state functional magnetic resonance imaging study of regional homogeneity and functional connectivity

机译：童年创伤年轻健康成年人的内在脑异常：区域均匀性和功能连通性的休息状态功能磁共振成像研究

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Objective: Childhood trauma confers great risk for the development of multiple psychiatric disorders; however, the neural basis for this association is still unknown. The present resting-state functional magnetic resonance imaging study aimed to detect the effects of childhood trauma on brain function in a group of young healthy adults. Methods: In total, 24 healthy individuals with childhood trauma and 24 age- and sex-matched adults without childhood trauma were recruited. Each participant underwent resting-state functional magnetic resonance imaging scanning. Intra-regional brain activity was evaluated by regional homogeneity method and compared between groups. Areas with altered regional homogeneity were further selected as seeds in subsequent functional connectivity analysis. Statistical analyses were performed by setting current depression and anxiety as covariates. Results: Adults with childhood trauma showed decreased regional homogeneity in bilateral superior temporal gyrus and insula, and the right inferior parietal lobule, as well as increased regional homogeneity in the right cerebellum and left middle temporal gyrus. Regional homogeneity values in the left middle temporal gyrus, right insula and right cerebellum were correlated with childhood trauma severity. In addition, individuals with childhood trauma also exhibited altered default mode network, cerebellum-default mode network and insula-default mode network connectivity when the left middle temporal gyrus, right cerebellum and right insula were selected as seed area, respectively. Conclusion: The present outcomes suggest that childhood trauma is associated with disturbed intrinsic brain function, especially the default mode network, in adults even without psychiatric diagnoses, which may mediate the relationship between childhood trauma and psychiatric disorders in later life.
机译：目的：儿童创伤赋予了多种精神病患者发展的巨大风险;然而，这种关联的神经基础仍然是未知的。目前休息状态的功能磁共振成像研究旨在检测儿童创伤对一群年轻健康成年人脑功能的影响。方法：招募了总共24例健康患有儿童创伤的健康个体和24名没有儿童创伤的年龄和性别匹配的成年人。每个参与者接受休息状态功能磁共振成像扫描。区域均匀性方法评估区域内脑活动，并在组之间进行比较。在随后的功能连通性分析中进一步选择具有改变的区域均匀性的区域。通过将当前的抑郁和作为协变量的焦虑设定为统计分析。结果：儿童创伤的成年人表现出双边颞率和肠道的区域均匀性下降，以及右下髓叶片，以及右侧小脑和左中间时颞升的区域均匀性。左中间颞克鲁斯，右侧肠道和右小脑中的区域均匀性值与儿童创伤严重程度相关。此外，患儿童创伤的个体也表现出默认模式网络的改变，当左中间颞型转血，右侧小脑和右侧Inslua分别被选择为种子区域时，小脑默认模式网络和Inslula-默认模式网络连接。结论：目前的结果表明，即使没有精神病诊断，儿童创伤与患有干扰的内在脑功能，尤其是默认模式网络，尤其是没有精神诊断，这可能会在后期生命中介绍儿童创伤和精神病患者之间的关系。

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