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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Ventricular volumes across stages of schizophrenia and other psychoses
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Ventricular volumes across stages of schizophrenia and other psychoses

机译：跨精神分裂症和其他精神上的阶段的心室卷

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Objective: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and first-episode psychosis studies are inconclusive. This study aims to investigate ventricular volumes at different stages of psychosis. Methods: Ventricular volumes were measured using a semi-automated and highly reliable method, for 89 established schizophrenia, 162 first-episode psychosis, 135 ultra high-risk for psychosis and 87 healthy controls using 1.5T magnetic resonance images. Clinical outcome diagnoses for ultra high-risk for psychosis were evaluated at long-term follow-up (mean: 7.5?years). Results: Compared to controls, we identified significant ventricular enlargement of 36.2% in established schizophrenia ( p ??0.001). Ventricular enlargement was not significant in first-episode psychosis (6%) or ultra high-risk for psychosis (?3%). Examination across stages of schizophrenia-spectrum diagnoses subgroups revealed a significant linear trend ( p ?=?0.006; established schizophrenia?=?36.2%, first-episode psychosis schizophrenia?=?18.5%, first-episode psychosis schizophreniform?=??4.2% and ultra high-risk for psychosis-schizophrenia converters?=??18.5%). Conclusion: Ventricular enlargement is apparent in patients with established schizophrenia but is not a feature at the earliest stages of illness (ultra high-risk for psychosis and first-episode psychosis). Further research is needed to fully characterize the nature and timing of ventricular volume changes early in the course of illness and how these changes impact outcomes. ]]>
机译：目的：既定精神分裂症患心室扩大常见;然而，来自精神病和第一集集精神病研究的超高风险的数据不确定。本研究旨在调查精神病的不同阶段的心室体积。方法：使用半自动和高度可靠的方法测量心室体积，89例成熟的精神分裂症，162名第一集精神病，135兆高风险，有效的精神病和87个健康控制使用1.5T磁共振图像。在长期随访中评估了精神病超高风险的临床结果诊断（平均：7.5？年）。结果：与对照相比，我们在已建立的精神分裂症中鉴定了36.2％的显着性心室增大（P？＆ 0.001）。心理症的心理学症（6％）或超高风险在心理学（？3％）中不显着。跨阶段的精神分裂症诊断局部诊断亚组揭示了显着的线性趋势（p？= 0.006;成熟的精神分裂症？=？36.2％，第一发作精神病精神分裂症？= 18.5％，第一集精神病精神分裂症？= ?? 4.2精神病 - 精神分裂转换器的％和超高风险？= ?? 18.5％）。结论：患有成熟精神分裂症患者的心室扩大是显而易见的，但不是最早疾病阶段的特征（超高风险的精神病和第一集精神病）。需要进一步研究，以充分表征心室体积的性质和时机在疾病过程中早期变化以及这些变化如何影响结果。 ]]>

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