...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Altered cerebellar functional connectivity in remitted bipolar disorder: A resting-state functional magnetic resonance imaging study
【24h】

Altered cerebellar functional connectivity in remitted bipolar disorder: A resting-state functional magnetic resonance imaging study

机译：剩余双极性障碍中改变的小脑功能连通性：静态功能磁共振成像研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: Several recent studies have reported a strong association between the cerebellar structural and functional abnormalities and psychiatric disorders. However, there are no studies to investigate possible changes in cerebellar functional connectivity in bipolar disorder. This study aimed to examine the whole-brain functional connectivity pattern of patients with remitted bipolar disorder II, in particular in the cerebellum. Methods: A total of 25 patients with remitted bipolar disorder II and 25 controls underwent resting-state functional magnetic resonance imaging and neuropsychological tests. Voxel-wise whole-brain connectivity was analyzed using a graph theory approach: functional connectivity strength. A seed-based resting-state functional connectivity analysis was further performed to investigate abnormal functional connectivity pattern of those regions with changed functional connectivity strength. Results: Remitted bipolar disorder II patients had significantly decreased functional connectivity strength in the bilateral posterior lobes of cerebellum (mainly lobules VIIb/VIIIa). The seed-based functional connectivity analyses revealed decreased functional connectivity between the right posterior cerebellum and the default mode network (i.e. right posterior cingulate cortex/precuneus and right superior temporal gyrus), bilateral hippocampus, right putamen, left paracentral lobule and bilateral posterior cerebellum and decreased functional connectivity between the left posterior cerebellum and the right inferior parietal lobule and bilateral posterior cerebellum in patients with remitted bipolar disorder II. Conclusion: Our results suggest that cerebellar dysconnectivity, in particular distributed cerebellar–cerebral functional connectivity, might be associated with the pathogenesis of bipolar disorder.
机译：目的：最近的几项研究报告了小脑结构和功能异常和精神疾病之间的强烈关联。然而，没有研究以研究双极性障碍中小脑功能性连通性的可能变化。本研究旨在探讨患有患者双极性障碍II的患者的全脑功能连通性，特别是在小脑中。方法：共25例剩余双相障碍患者II和25例对照进行休息状态功能磁共振成像和神经心理学检测。使用图形理论方法分析Voxel-Wise全脑连接：功能连接强度。进一步进行了一种基于种子的静态功能连接分析以研究这些区域的异常功能连通性图案，随着功能性连体强度改变。结果：饲养的双极性障碍II患者在小脑双侧后叶中具有显着降低的功能连体强度（主要是Lobules VIIB / VIIIA）。基于种子的功能连接分析显示右后脑细胞和默认模式网络之间的功能性连通性降低（即右后刺型皮层/前右颞次颞克鲁斯），双侧海马，右腐败，左侧斜纹和双侧后部小脑和双侧后部减少左后小脑和右下耳廓叶片之间的功能连通性，患者双极性障碍患者II患者。结论：我们的研究结果表明，小脑脱节性，特别是分布的小脑 - 脑功能连通性，可能与双相障碍的发病机制有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号