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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Mood disturbance after infection
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Mood disturbance after infection

机译：感染后情绪障碍

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Objective: An aetiological link between acute infection and major depression has long been hypothesized, and is increasingly gaining recognition within contemporary literature. This review aims to examine the evidence for such a link, specifically between acute, self-limiting infection and major depression, and to summarize the current understanding of pathophysiological mechanisms underlying this link. Methods: Relevant articles were sourced via an online search of published literature from Embase, MEDLINE, PsycINFO and PubMed using a variety of search terms including mood disorder, depression, infection and inflammation. Additionally, a search for articles from the bibliographies of retrieved papers was conducted. Results: Findings from retrospective studies suggest an association between infection and subsequent mood disturbance, including major depression. This association has been confirmed by studies employing prospective observational or experimental challenge designs. The available evidence supports a multifactorial basis of vulnerability towards major depression in the context of acute infection. Genetic, neuroendocrine, autonomic and psychosocial factors may interact to potentiate the likelihood of a severe and prolonged depressive response to an immunological stressor in some individuals. Conclusion: Mood disturbance is likely to have a host-protective role in the context of an acute sickness response to infection. However, this usually adaptive and reversible response may progress in some vulnerable individuals into a more sustained and severe pattern of behavioural and physiological changes of major depression. Further research is needed to delineate the factors that predispose, precipitate and perpetuate depression in the context of acute infective illness. Such insights will inform effective prevention and treatment strategies.
机译：目的：急性感染与重大抑郁症之间的安全性长期以来一直在假设，在当代文学中越来越受到认可。该审查旨在审查这种联系的证据，特别是在急性，自我限制的感染和重大抑郁症之间，并总结了目前对这一联系地下的病理生理机制的理解。方法：使用各种搜索术语从embase，Medline，Psycinfo和PubMed中搜索有关文献的相关文章，包括各种搜索术语，包括情绪障碍，抑郁，感染和炎症。另外，进行了从检索纸的书目搜索文章。结果：回顾性研究的结果表明，感染与随后的情绪干扰之间的关联，包括重大抑郁症。该协会通过采用预期观察或实验挑战设计的研究确认。可用证据支持在急性感染的背景下对主要抑郁症的脆弱性的多因素基础。遗传学，神经内分泌，自主主义和心理社会因素可以相互作用，以提高对某些人的免疫应激源的严重和长期抑郁反应的可能性。结论：情绪障碍可能在对感染的急性疾病反应的背景下具有宿主保护作用。然而，这种通常适应性和可逆的反应可能在一些脆弱的个人中进入重大抑郁症的更持续和严重的行为和生理变化模式。需要进一步的研究来描绘易感性，沉淀和长期抑制急性感染性疾病的因素。此类见解将提供有效的预防和治疗策略。

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