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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Significant relationship between lifetime alcohol use disorders and suicide attempts in an Australian schizophrenia sample
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Significant relationship between lifetime alcohol use disorders and suicide attempts in an Australian schizophrenia sample

机译：终身酒精使用障碍与澳大利亚精神分裂症样本的自杀企图之间的重要关系

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Objective: Suicide and attempted suicide are common in individuals with schizophrenia, and evidence exists for a link between substance use disorders and suicidality in this disorder. However, alcohol has not been consistently implicated. We examined the relationship between substance use disorders and suicide attempts in schizophrenia.Methods: We recruited a schizophrenia sample in Australia (n = 821) for genetic analyses. We analysed demographic and clinical variables, including substance use disorders, and their relationship to suicide attempts using generalised equation modelling.Results: A significant association was identified between lifetime alcohol abuse/dependence and suicide attempts (OR = 1.66; 95% CI, 1.23 to 2.24; p= 0.001) after adjustment for potential confounders, but not between cannabis abuse/dependence and suicide attempts, nor between other illicit drug abuse/dependence and suicide attempts. Polysubstance abuse/dependence was also not implicated.Conclusions: These results suggest that the presence of alcohol abuse/dependence may be a risk factor for suicide attempts in individuals with schizophrenia, independent of comorbid substance abuse/dependence.
机译：目的：自杀和企图的自杀于具有精神分裂症的个体中常见，并且存在对该疾病的物质使用障碍和自由性之间的联系。然而，酒精尚未持续牵连。我们研究了Schizophenia的物质使用障碍和自杀企图的自杀企图之间的关系。方法：我们招募了澳大利亚的精神分裂症样本（n = 821）进行遗传分析。我们分析了人口统计学和临床​​变量，包括物质使用障碍，以及使用广义方程式模拟的自杀企图的关系。结果：在终身酒精滥用/依赖性和自杀企图之间鉴定了重要关联（或= 1.66; 95％CI，1.23。 2.24; p = 0.001）调整潜在混淆后，但不在大麻滥用/依赖和自杀企图之间，也不是在其他非法药物滥用/依赖和自杀的尝试之间。多乌犬滥用/依赖也没有牵连。结论：这些结果表明，酒精滥用/依赖的存在可能是自杀患者在具有精神分裂症的个人中的危险因素，而独立于共用药物滥用/依赖性。

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