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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Do testosterone and brain-derived neurotrophic factor interactions play a role in the pathophysiology of suicidal behavior?
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Do testosterone and brain-derived neurotrophic factor interactions play a role in the pathophysiology of suicidal behavior?

机译:睾酮和脑源性神经营养因子相互作用是否在自杀行为的病理生理学中发挥作用?

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摘要

Suicide is a serious medical and social affliction that has severe emotional recourse for all persons involved. This phenomenon occurs in approximately one million people worldwide every year and has both psychological and neurobiological facets. Understanding the neurobiology of such a devastating event has been the focus of many recent research projects. Multiple lines of evidence suggest that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of suicide. For example, one such study revealed that patients with depression and suicidal behavior had lower plasma levels of BDNF (Sher, 2011). Another study showed decreased levels of BDNF in the hippocampus and prefrontal cortex in post-mortem brains of patients who had committed suicide (Sher,2011).
机译:自杀是一个严重的医疗和社会痛苦,对所涉及的所有人都有严重的情感追索权。 这种现象每年在全球大约一百万人中发生,并且具有心理和神经生物学的面部。 了解这种毁灭事件的神经生物学一直是许多最近研究项目的重点。 多条证据表明脑衍生的神经营养因子(BDNF)参与自杀的病理生理学。 例如,一种这样的研究表明,抑郁症和自杀行为的患者具有较低的BDNF血浆水平(SHER,2011)。 另一项研究表明,致力于自杀的患者的验尸大脑中的海马和前额叶皮质水平降低(Sher,2011)。

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