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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Seasonal and temperature effect on serum lithium concentrations
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Seasonal and temperature effect on serum lithium concentrations

机译：对血清锂浓度的季节性和温度效应

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Background: Lithium remains the gold standard treatment for bipolar disorder. However, it has a very narrow therapeutic index (0.6–0.8 mmol/L). It has been suggested that high environmental temperature can lead to dehydration, elevated plasma lithium concentration and then lithium toxicity. Objectives: We aimed to investigate the effect of seasonal and short-term changes in temperature on serum lithium concentrations in Sydney, Australia. Methods: We retrospectively analysed data from all patients who had serum lithium concentrations taken from the Prince of Wales and Sutherland Hospitals between 2008 and 2018. Temperature data came from the Bureau of Meteorology. We examined correlations between lithium concentrations and the preceding 5?days maximum temperatures, month and season. We also performed a longitudinal analysis of the effect of temperature and seasons within selected patients who had repeated levels. Results: A total of 11,912 serum lithium concentrations from 2493 patients were analysed. There was no significant association between higher lithium concentration and preceding higher temperatures ( r ?=?–0.008, p ?=?0.399). There was also no important seasonal or monthly variation, across all patients or in the smaller cohort with longitudinal data ( n ?=?123, r ?=?0.008, 95% confidence interval: [–0.04, 0.06]). Conclusion: There were no clinically important differences in serum lithium concentration related to seasons, months or temperatures, which suggests that patients on lithium are able to adequately maintain hydration during hot weather in Sydney.
机译：背景：锂仍然是双相障碍的金标准治疗。然而，它具有非常窄的治疗指数（0.6-0.8mmol / L）。已经提出，高环境温度可导致脱水，升高的血浆锂浓度，然后锂毒性。目的：我们旨在探讨澳大利亚悉尼血清锂浓度温度季节性和短期变化的影响。方法：我们回顾性地分析了来自威尔士王子和苏瑟兰医院的所有患者的所有患者的数据，2008年至2018年间。气象局来自气象局。我们检查了锂浓度与前5个的相关性，最高温度，月和季节。我们还对重复水平的选定患者的温度和季节的影响进行了纵向分析。结果：分析了来自2493名患者的11,912个血清锂浓度。在锂浓度高出和在更高的温度之前没有显着关联（R？=Δ - 0.008，p？= 0.399）。在所有患者中也没有重要的季节性或每月变异，或者在纵向数据（n？= 123，r？= 0.008，95％置信区间：[-0.04,0.06]）。结论：与季节，月份或温度有关的血清锂浓度没有临床上重要差异，这表明锂患者能够在悉尼的炎热天气中充分维持水合。

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