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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Metabolite profiles in the anterior cingulate cortex of depressed patients differentiate those taking N-acetyl-cysteine versus placebo.
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Metabolite profiles in the anterior cingulate cortex of depressed patients differentiate those taking N-acetyl-cysteine versus placebo.

机译：抑制患者的前铰接皮质中的代谢物谱分化了那些服用N-乙酰半胱氨酸与安慰剂的那些。

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Increased oxidative stress is thought to contribute to the pathophysiology of major depressive disorder (MDD), which is in part due to diminished levels of glutathione, the primary anti-oxidant of the brain. Oral administration of N-acetyl-cysteine (NAC) replenishes glutathione and has therefore been shown to reduce depressive symptoms. Proton magnetic spectroscopy ((1)H-MRS) that allows quantification of brain metabolites pertinent to both MDD and oxidative biology may provide some novel insights into the neurobiological effects of NAC, and in particular metabolite concentrations within the anterior cingulate cortex (ACC) are likely to be important given the key role of this region in the regulation of affect.The aim of this study was to determine whether the metabolite profile of the ACC in MDD patients predicts treatment with adjunctive NAC versus placebo.This study was nested within a multicentre, randomized, double-blind, placebo-controlled study of MDD participants treated with adjunctive NAC. Participants (n = 76) from one site completed the spectroscopy component at the end of treatment (12 weeks). Spectra from a single-voxel in the ACC were acquired and absolute concentrations of glutamate (Glu), glutamate-glutamine (Glx), N-acetyl-aspartate (NAA) and myo-inositol (mI) were obtained. Binary logistic regression analysis was performed to determine whether metabolite profiles could predict NAC versus placebo group membership.When predicting group outcome (NAC or placebo), Glx, NAA and mI were a significant model, and had 75% accuracy, while controlling for depression severity and sex. However, the Glu, NAA and mI profile was only predictive at a trend level, with 68.3% accuracy. For both models, the log of the odds of a participant being in the NAC group was positively related to NAA, Glx and Glu levels and negatively related to mI levels.The finding of higher Glx and NAA levels being predictive of the NAC group provides preliminary support for the putative anti-oxidative role of NAC in MDD.
机译：据认为增加氧化应激是有助于主要抑郁症（MDD）的病理生理学，这部分是由于谷胱甘肽水平降低，脑的初级抗氧化剂。施用N-乙酰基半胱氨酸（NAC）补充谷胱甘肽，因此已被证明减少抑郁症状。质子磁光谱（（1）H-MRS），其允许与MDD和氧化生物学相关的脑代谢物定量可以提供一些新颖的洞察NAC的神经生物学作用，并且特别是前铰链皮质（ACC）内的代谢物浓度是鉴于该地区在受影响的调节方面的关键作用可能很重要。本研究的目的是确定MDD患者中ACC的代谢物剖面是否预测辅助NAC与安慰剂的治疗。本研究嵌套在多中心内，随机，双盲，安慰剂对照研究，辅助NAC治疗的MDD参与者。来自一个网站的参与者（n = 76）在治疗结束时完成了光谱分量（12周）。获取来自单体中的单voxel的光谱，获得谷氨酸（Glu），谷氨酸 - 谷氨酰胺（Glx），N-乙酰 - 天冬氨酸（NAA）和肌肌醇（MI）的绝对浓度。进行二元逻辑回归分析以确定代谢物简档是否可以预测NAC与安慰剂组成员身份。预测群体结果（NAC或安慰剂），GLX，NAA和MI是一个重要的模型，精度75％，同时控制抑郁严重程度和性。然而，Glu，NAA和MI型材仅在趋势水平上预测，精度为68.3％。对于这两种模型，参与者在NAC组中的几率的日志与NAA，GLX和GLU水平正相关，并且与MI水平负相关。寻找更高的GLX和NAA水平是预测NAC组的初步提供初步支持NAC在MDD中的推定抗氧化作用。

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