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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Cumulative childhood interpersonal trauma is associated with reduced cortical differentiation between threat and non-threat faces in posttraumatic stress disorder adults
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Cumulative childhood interpersonal trauma is associated with reduced cortical differentiation between threat and non-threat faces in posttraumatic stress disorder adults

机译：累积儿童人际关重的创伤与错误后应激障碍成年人的威胁和非威胁面之间的皮质分化减少相关

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Objective: Posttraumatic stress disorder and childhood trauma frequently co-occur. Both are associated with abnormal neural responses to salient emotion stimuli. As childhood trauma is a risk factor for posttraumatic stress disorder, differentiating between their neurophysiological effects is necessary to elucidate the neural pathways by which childhood trauma exposure contributes to increased posttraumatic stress disorder risks. Methods: Face-specific N170 evoked response potentials for backward-masked (non-conscious) and conscious threat (fear, angry) and non-threat (happy) faces were measured in 77 adults (18-64 years old, 64% women, 78% right-handed) symptomatic for posttraumatic stress disorder. Differences in N170 peak amplitudes for fear-versus-happy and angry-versus-happy faces at bilateral temporo-occipital (T5, T6) sites were computed. The effect of cumulative exposure to childhood interpersonal trauma, other childhood trauma, adult trauma, depression and posttraumatic stress disorder symptom severity on the N170 response was assessed using hierarchical multiple regression analyses. Results: T5 N170 peak amplitudes for non-conscious fear-versus-happy faces were inversely related to cumulative childhood interpersonal trauma after accounting for socio-demographic, clinical symptom and other trauma factors. Posttraumatic stress disorder Avoidance was positively associated with N170 peak amplitudes for non-conscious fear-versus-happy faces, primarily due to reduced N170 responsivity to happy faces. Conclusion: Childhood interpersonal trauma exposure is associated with reduced discrimination between fear and happy faces, while avoidance symptom severity is associated with dampened responsivity to automatically processed happy faces in posttraumatic stress disorder adults. Results are discussed in terms of the likely contributions of impaired threat discrimination and deficient reward processing during neural processing of salient emotion stimuli, to increased risks of posttraumatic stress disorder onset and chronicity in childhood interpersonal trauma-exposed adults.
机译：目的：术后应激障碍和儿童创伤经常共同发生。两者都与突出情绪刺激的异常神经反应相关。由于儿童创伤是错误患者应激障碍的危险因素，但它们的神经生理学效应之间的区别是阐明童年创伤暴露导致的患者失调障碍风险增加的神经途径。方法：面对蒙面（无意识）和有意识的威胁（恐惧，愤怒）和非威胁（快乐）面部的诱发响应潜力（18-64岁，64％， 78％右手的）症状对宫外应激障碍。计算了双边临时（T5，T6）站点的恐惧与快乐且愤怒的愤怒和快乐的面孔的N170峰值幅度的差异。使用分级多元回归分析评估了累积暴露于儿童人际创伤，其他儿童创伤，成人创伤，抑郁和抑郁症对N170响应的症状严重程度的症状严重程度。结果：T5 N170非意识恐惧 - 与快乐的面孔的峰值幅度与累计儿童人际关重要的累计有关，核算社会人口，临床症状和其他创伤因素。避免前后应激障碍与非意识恐惧与快乐面孔的N170峰值振幅正相关，主要是由于对快乐面的N170响应性降低。结论：儿童人际创牙暴露与恐惧和快乐面临的歧视减少有关，而避免症状严重程度与抑制反应性有关，以自动加工患者患者应激障碍成年人的快乐面。结果讨论了威胁歧视和缺乏突出情绪刺激期间危害奖励加工缺乏奖励加工的结果，以增加儿童人工间创伤成年人的失调患者失调和慢性的风险。

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