...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The anatomical record: advances in integrative anatomy and evolutionary biology >Uterine Receptivity in Merriam's Kangaroo Rat ( Dipodomys merriami Dipodomys merriami Dipodomys merriami )
【24h】

Uterine Receptivity in Merriam's Kangaroo Rat ( Dipodomys merriami Dipodomys merriami Dipodomys merriami )

机译：Merriam's Kangaroo Rat（Cicangs Merriami Cimodomys Merriadman Tigodomys Merriami）的子宫接受性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

ABSTRACT The uterine surface undergoes significant remodeling, termed the “plasma membrane transformation,” during pregnancy to allow for implantation of the blastocyst and formation of the placenta in viviparous amniote vertebrates. Unlike other species within the superorder Euarchontoglires, which have a hemochorial (highly invasive) placenta, kangaroo rats ( Dipodomys spp.) exhibit a less invasive endotheliochorial placenta. We characterized the changes that occur to membrane molecules and the cellular ultrastructure of the uterine epithelium during early pregnancy in Merriam's kangaroo rat, Dipodomys merriami using electron microscopy and immunofluorescence microscopy. Epithelial cadherin (E‐cadherin) is an adhesion protein that forms the adherens junction and is localized to the lateral plasma membrane of uterine epithelium during the nonreproductive state but localizes nonspecifically in the uterine epithelium immediately preceding implantation. Desmosomes are a type of cadherin that form junctional complexes along the lateral plasma membrane of epithelium. Dsg‐2, a marker for desmosomes, is localized along the lateral plasma membrane in non‐pregnant animals but redistributes to the apical region of the lateral plasma membrane during early pregnancy. The shift in desmosome and cadherin distribution before implantation suggests that there is a reduction in lateral adhesion between epithelial cells to allow for invasion by the blastocyst. Surprisingly, although Kangaroo rats form a less invasive placenta, these same changes occur during pregnancy in species with highly invasive placentation, such as the laboratory rat and human. These commonalities suggest that it is not through the retention of lateral adhesion that the blastocyst is prevented from further invasion in this rodent species. Anat Rec, 301:1928–1935, 2018. ? 2018 Wiley Periodicals, Inc.
机译：摘要子宫表面经历显着的重塑，称为妊娠期间的“血浆膜转化”，以允许植入胚泡和形成胎盘在viviparous amniote脊椎动物中的形成。与超级欧盟校星中的其他物种不同，该物种具有椎间目（高度侵入性）胎盘，袋鼠大鼠（Dipodomys SPP）。表现出较少的侵入内皮胎盘。我们的特征在于使用电子显微镜和免疫荧光显微镜，Dipodomys Merriami早期怀孕期间发生膜分子和子宫上皮细胞超微结构的变化。使用电子显微镜和免疫荧光显微镜。上皮钙粘蛋白（E-cadherin）是一种粘附蛋白，其形成粘附结，并且在非培养状态下局部到子宫上皮的横向质膜，但是在紧接在植入前的子宫上皮内非渗透地定位。 DESMOSOMES是一种一种钙粘蛋白，其沿着上皮的横向浆料形成结络合物。 DSG-2，脱染粒子的标记物，沿着非妊娠动物的横向血浆膜定位，而是在妊娠期间重新分配到横向血浆膜的顶端区域。在植入前的去皮组和钙粘蛋白分布的转变表明，上皮细胞之间的横向粘附性降低，以允许胚泡侵入。令人惊讶的是，虽然袋鼠大鼠形成了较少的侵袭性胎盘，但在妊娠期间发生了相同的变化，具有高度侵袭性沉默，如实验室大鼠和人类。这些常见表明它不是通过保留横向粘附的保留，即防止胚泡在这种啮齿动物物种中进一步侵袭。 ANAT REC，301：1928-1935,2018 2018年Wiley期刊，Inc。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号