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首页> 外文期刊>The anatomical record: advances in integrative anatomy and evolutionary biology >Xiaoyaosan regulates depression-related behaviors with physical symptoms by modulating Orexin A/OxR1 in the hypothalamus
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Xiaoyaosan regulates depression-related behaviors with physical symptoms by modulating Orexin A/OxR1 in the hypothalamus

机译：小雅索桑通过调节下丘脑中的orexin a / oxr1来调节与物理症状的抑郁相关行为

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摘要

The functional regulation of the orexin system in the central nervous system is closely related to the occurrence and development of psychotic disorders. Abnormal changes in the lateral region of the hypothalamus are associated with the comorbidity of depression and physical symptoms, and how the traditional Chinese formula Xiaoyaosan regulates these changes may reveal aspects of the pathogenesis of depression. This study aimed to establish a rat model of depression in order to examine changes in Orexin A/OxR1 expression in the lateral region of the hypothalamus and the effects of Xiaoyaosan. Sixty specific pathogen-free (SPF) male healthy Sprague-Dawley (SD) rats were used in the experiment and randomly divided into the control group, the model group, the Xiaoyaosan group and the fluoxetine group. The depression model was established by 21-day chronic immobilization stress (CIS). Food intake and body weight were recorded, and the sucrose preference test (SPT) and open field test (OFT) were used to evaluate the model.Then, the expression of Orexin A/OxR1 in the hypothalamus was measured by ELISA, Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) analysis.The expression of Orexin A and OxR1 in the lateral hypothalamic area was significantly down regulated in the model group, compared with the control group. Xiaoyaosan significantly reversed these changes with obvious curative effects. Abnormal changes in Orexin A/OxR1 in the lateral hypothalamic area of rats with depression caused by chronic stress are closely related to the pathogenesis of depression accompanied by physical symptoms.Xiaoyaosan can improve depression accompanied by physical symptoms by regulating Orexin A/OxR1.
机译：中枢神经系统中的orexin系统的功能调节与精神病障碍的发生和发展密切相关。下丘脑的侧面区域的异常变化与抑郁和物理症状的合并症相关，以及传统的中式撇子索兰如何调节这些变化可能会揭示抑郁症发病机制的方面。本研究旨在建立一种抑郁大鼠模型，以检查下丘脑侧面的orexina / oxr1表达的变化及小川的作用。在实验中使用六十个特异性病原体（SPF）男性健康Sprague-Dawley（SD）大鼠，随机分为对照组，模型组，小川组和氟西汀组。抑郁模型由21天的慢性固定胁迫（CIS）建立。记录食物摄入和体重，并且使用蔗糖偏好测试（SPT）和开放的场测试（OFT）来评估模型。然后，通过ELISA，Western印迹和丘脑中所述的丘脑中的orexina / OxR1的表达。定量实时聚合酶链反应（QRT-PCR）分析。与对照组相比，在模型组中，在侧丘脑区域中的orexina和oxR1的表达显着下降。萧亚斯汉显着扭转了这些变化，具有明显的疗效。由慢性胁迫引起的抑郁症引起的抑郁症引起的大鼠侧下丘脑区域的异常变化与抑郁症的发病机制密切相关，伴随着身体症状。通过调节orexin a / oxr1，雄黄可以改善伴有物理症状的抑郁症。

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