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首页> 外文期刊>The anatomical record: advances in integrative anatomy and evolutionary biology >Mitochondrial Deformation During the Cardiac Mechanical Cycle
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Mitochondrial Deformation During the Cardiac Mechanical Cycle

机译：心脏机械循环期间的线粒体变形

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Cardiomyocytes both cause and experience continual cyclic deformation. The exact effects of this deformation on the properties of intracellular organelles are not well characterized, although they are likely to be relevant for cardiomyocyte responses to active and passive changes in their mechanical environment. In the present study we provide three-dimensional ultrastructural evidence for mechanically induced mitochondrial deformation in rabbit ventricular cardiomyocytes over a range of sarcomere lengths representing myocardial tissue stretch, an unloaded slack state, and contracture. We also show structural indications for interaction of mitochondria with one another, as well as with other intracellular elements such as microtubules, sarcoplasmic reticulum and T-tubules. The data presented here help to contextualize recent reports on the mechanosensitivity and cell-wide connectivity of the mitochondrial network and provide a structural framework that may aide interpretation of mechanically-regulated molecular signaling in cardiac cells. Anat Rec, 302:146-152, 2019. (c) 2018 The Authors. The Anatomical Record published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists.
机译：心肌细胞既有原因，经历持续的循环变形。这种变形对细胞内细胞器的性质的确切效果并不具备很好的表征，尽管它们可能与心肌细胞反应相关，以对其机械环境的主动和被动变化的反应。在本研究中，我们提供三维超微结构证据，用于机械诱导的兔心室心肌细胞的线粒体变形在一系列肉体长度，代表心肌组织延伸，卸载的松弛状态和挛缩。我们还表明了彼此的线粒体相互作用的结构适应症，以及其他细胞内元素，如微管，肌肉浆瘤和T型管。这里介绍的数据有助于上下文化最近关于线粒体网络的机械敏感性和细胞宽连接的报告，并提供一种结构框架，其可以在心脏细胞中融合机械调节的分子信号的解释。 ANAT REC，302：146-152,2019。（c）2018年作者。 Wiley期刊，Inc。代表美国的解剖学家协会出版的解剖记录。

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