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首页> 外文期刊>The breast journal >Failure of sentinel lymph node mapping in breast cancer patients qualified for treatment sparing axillary lymph nodes—Clinical importance and management strategy—One‐center analysis
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Failure of sentinel lymph node mapping in breast cancer patients qualified for treatment sparing axillary lymph nodes—Clinical importance and management strategy—One‐center analysis

机译：乳腺癌患者患者的乳腺癌淋巴结映射失败，患有治疗腋窝淋巴结的疾病症状 - 临床重要性与管理战略 - 单中心分析

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Abstract Sentinel lymph node biopsy (SLNB) is a standard in diagnostic and therapeutic management of patients with nonadvanced invasive breast cancer. The aim of this paper was to evaluate the clinical importance of the failure of sentinel lymph node (SLN) identification during SLNB performed to spare axillary lymph nodes. A total of 5396 patients with invasive breast cancer qualified for SLNB, treated in a period from Jan 2004 to June 2018. All cases of the failure of SLN identification and reasons underlying this situation were analyzed retrospectively. In 196 (3.6%) patients, SLN was not identified (group I), and this resulted in a simultaneous axillary lymph node dissection. 48.5% patients from this group were diagnosed with cancer metastases to lymph nodes (vs 23.6% patients with SLN removed—group II, P ??.00001)—stage pN1 in 44.2% of the cases, stage pN2 in 22.1% of the cases, and pN3 in 33.7% (in group II—73.4%, 19.5% and 7.1%, respectively), with a presence of extracapsular infiltration in 68.4% patients (vs 41.7% in group II) and with a significantly higher percentage of micrometastatic nature in group II (17.0%, vs 3.2% in group I). The failure of intraoperative sentinel lymph node mapping indicates a significantly increased risk of breast cancer metastases to the axillary lymph system. At the same time, it can also indicate higher cancer stage and its increased aggressiveness. For this reason, in such situation performance of axillary lymph node dissection still appears to be the approach most advantageous for patients.
机译：摘要的Sentinel淋巴结活检（SLNB）是诊断和治疗患者的诊断和治疗患者的标准。本文的目的是评估SLNB在备用腋窝淋巴结期间的Sentinel淋巴结（SLN）鉴定失败的临床重要性。共有5396名患有SLNB的侵袭性乳腺癌患者，在2004年1月至2018年6月待遇。回顾性地分析了所有案件的SLN识别失败和原因的所有案件。 196年（3.6％）患者，未鉴定SLN（I组），这导致同时腋窝淋巴结解剖。 48.5％来自该组的患者被诊断患有癌症转移到淋巴结（VS 23.6％的SLN除去-1族患者II，p≤00001）-Stage PN1在44.2％的情况下，PN2中的22.1％该病例和PN3分别为33.7％（分别为II-73.4％，分别为19.5％和7.1％），在68.4％的患者中存在折射率浸润（II组的41.7％），并且具有明显更高的百分比II组的微转移性质（17.0％，Ⅰ组中的3.2％）。术中哨淋淋巴结映射的失败表明腋生淋巴结的乳腺癌转移风险显着增加。同时，它也可以表明癌症阶段更高，增加的侵略性。因此，在腋窝淋巴结解剖的这种情况下，仍然是患者最有利的方法。

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