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首页> 外文期刊>The clinical respiratory journal. >Role of monocyte tissue factor on patients with non‐small cell lung cancer
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Role of monocyte tissue factor on patients with non‐small cell lung cancer

机译：单核细胞组织因子对非小细胞肺癌患者的作用

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摘要

Abstract Background To examine the expression of D‐dimer, fibrinogen (FIB), leukocyte, C‐reactive protein (CRP) and tissue factor (TF) released from monocyte in non‐small cell lung cancer (NSCLC) patients with or without venous thromboembolism (VTE) and analyse the correlation, to explore the possible mechanisms. Methods Seventy‐two patients confirmed the diagnosis of lung cancer, among whom 10 with VTE were enrolled into the study from November 2012 to January 2014 in the First Affiliated Hospital of Fujian Medical University and 30 healthy subjects were also enrolled as the control group. Ficoll and Percoll density gradient centrifugation separated of peripheral blood monocyte. Monocyte TF mRNA expression was detected using reverse transcriptase‐polymerase chain reaction (RT‐PCR). Results There were significant differences in different stages of the cancer ( P ??.05) and no significance among the histopathologic types ( P ??.05) for the expression of monocyte TF mRNA in NSCLC patients, its expression was significantly higher in cancer with lymph node metastasis than those without lymph node metastasis ( P ??.01). Meanwhile, in NSCLC patients with VTE, the expression of monocyte TF mRNA was significantly higher than that in patients without VTE ( P ??.01). Difference of the survival curves between the low monocyte TF mRNA expression and the high monocyte TF mRNA expression was significant (Log‐rank x2?=?4.923, P ??.05). Conclusions Monocyte TF may be a relevant source of TF‐mediated thrombogenicity in NSCLC patients and may be associated with prognosis in NSCLC.
机译：摘要背景，用于在非小细胞肺癌（NSCLC）患者中从单核细胞中释放的D-二聚体，纤维蛋白原（FIB），白细胞，C反应蛋白（CRP）和组织因子（TF）的表达背景（NSCLC）患者或没有静脉血栓栓塞（VTE）并分析相关性，探索可能的机制。方法七十二名患者证实了肺癌的诊断，其中vteb于2012年11月至2014年1月入学于福建医科大学第一个和2014年1月，30名健康受试者还为对照组注册。 Ficoll和Percoll密度梯度离心分离外周血单核细胞。使用逆转录酶 - 聚合酶链反应（RT-PCR）检测单核细胞TF mRNA表达。结果癌症的不同阶段存在显着差异（p？＆ 05），组织病理学类型（p≤0.05）在NSCLC患者中单核细胞TF mRNA的表达没有显着性，其表达是癌癌显着高于淋巴结转移，而不是没有淋巴结转移的癌症（P？＆ 01）。同时，在NSCLC患者的VTE中，单核细胞TF mRNA的表达明显高于没有VTE的患者（P = 01）的患者。低单核细胞TF mRNA表达与高单核细胞TF mRNA表达之间的存活曲线的差异是显着的（对数级x2？=Δ.4.923，p？05）。结论单核细胞TF可以是NSCLC患者中TF介导的血栓形成性的相关来源，并且可能与NSCLC预后有关。

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  • 来源
    《The clinical respiratory journal.》 |2018年第3期|共9页
  • 作者

    Deng Chaosheng; Wu Shuang; Zhang Lina; Yang Minxia; Lin Qichang; Xie Qiang; Ding Haibo; Lian Ningfang; Gao Shaoyong; Huang Yunjian; Jin Yongxu;

  • 作者单位

    Division of Respiratory and Critical Care MedicineFirst Affiliated Hospital of Fujian Medical;

    Division of Respiratory and Critical Care MedicineFirst Affiliated Hospital of Fujian Medical;

    Department of Respiratory Diseasethe Chinese People's Liberation Army 155 Central HospitalLuoyang;

    Department of Critical Care MedicineFirst Affiliated Hospital Fujian Medical UniversityFuzhou;

    Division of Respiratory and Critical Care MedicineFirst Affiliated Hospital of Fujian Medical;

    Fuzhou Pulmonary Hospital in Fujian ProvinceFuzhou Fujian Province China;

    Division of Respiratory and Critical Care MedicineFirst Affiliated Hospital of Fujian Medical;

    Division of Respiratory and Critical Care MedicineFirst Affiliated Hospital of Fujian Medical;

    Division of Respiratory and Critical Care MedicineFirst Affiliated Hospital of Fujian Medical;

    Fujian Provincial Tumor hospitalFuzhou Fujian Province China;

    Division of Respiratory and Critical Care MedicineFirst Affiliated Hospital of Fujian Medical;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 呼吸系及胸部疾病;
  • 关键词

    non‐small cell lung cancer; monocyte; tissue factor; D‐dimer; fibrinogen; venous thromboembolism;

    机译：非小细胞肺癌;单核细胞;组织因子;D-二聚体;纤维蛋白原;静脉血栓栓塞;

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