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首页> 外文期刊>The British journal of psychiatry : >Evaluation of functional connectivity in subdivisions of the thalamus in schizophrenia
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Evaluation of functional connectivity in subdivisions of the thalamus in schizophrenia

机译：精神分裂症中丘脑细分中功能连通性的评价

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摘要

Background Previous studies in schizophrenia revealed abnormalities in the cortico-cerebellar-thalamo-cortical circuit (CCTCC) pathway, suggesting the necessity for defining thalamic subdivisions in understanding alterations of brain connectivity. Aims To parcellate the thalamus into several subdivisions using a data-driven method, and to evaluate the role of each subdivision in the alterations of CCTCC functional connectivity in patients with schizophrenia. Method There were 54 patients with schizophrenia and 42 healthy controls included in this study. First, the thalamic structural and functional connections computed, based on diffusion magnetic resonance imaging (MRI, white matter tractography) and resting-state functional MRI, were clustered to parcellate thalamus. Next, functional connectivity of each thalamus subdivision was investigated, and the alterations in thalamic functional connectivity for patients with schizophrenia were inspected. Results Based on the data-driven parcellation method, six thalamic subdivisions were defined. Loss of connectivity was observed between several thalamic subdivisions (superior-anterior, ventromedial and dorsolateral part of the thalamus) and the sensorimotor system, anterior cingulate cortex and cerebellum in patients with schizophrenia. A gradual pattern of dysconnectivity was observed across the thalamic subdivisions. Additionally, the altered connectivity negatively correlated with symptom scores and duration of illness in individuals with schizophrenia. Conclusions The findings of the study revealed a wide range of thalamic functional dysconnectivity in the CCTCC pathway, increasing our understanding of the relationship between the CCTCC pathway and symptoms associated with schizophrenia, and further indicating a potential alteration pattern in the thalamic nuclei in people with schizophrenia. Declaration of interest None.
机译：背景技术精神分裂症的先前研究显示了皮质脑 - 丘脑 - 皮质电路（CCTCC）途径的异常，表明在理解脑连接的改变时定义丘脑细分的必要性。旨在使用数据驱动方法将丘脑置于几个细分中，并评估每种细胞在精神分裂症患者中CCTCC功能连接的改变中的作用。方法中有54例精神分裂症和42例健康对照组。首先，基于扩散磁共振成像（MRI，白质杂物牵引）和静态官能MRI计算计算的丘脑结构和功能连接被聚集到寄生丘脑。接下来，研究了每个丘脑细分的功能性连接，检查了精神分裂症患者的丘脑功能连通性的改变。结果基于数据驱动的局部局部方法，定义了六个丘脑细分。在患有精神分裂症患者的初步细分（丘脑高级，腹部，婴儿周期和背侧部分）和Sensimotor系统，前铰接皮质和小脑中，观察到连通性丧失。在丘脑细分中观察到逐渐渗透的模式。另外，改变的连通性与具有精神分裂症的个体症状评分和疾病持续时间呈负相关。结论该研究的结果揭示了CCTCC途径中的各种丘脑功能性困扰，增加了我们对与精神分裂症相关的症状与肠道症状之间的关系的理解，并进一步表明含有精神分​​裂症的丘脑中的潜在改变模式。申报感兴趣没有。

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  • 作者

    Gong Jinnan; Luo Cheng; Li Xiangkui; Jiang Sisi; Khundrakpam Budhachandra S.; Duan Mingjun; Chen Xi; Yao Dezhong;

  • 作者单位

    Univ Elect Sci &

    Technol China Ctr Informat Med MOE Key Lab Neuroinformat Chengdu Brain Sci Inst;

    Univ Elect Sci &

    Technol China Ctr Informat Med MOE Key Lab Neuroinformat Chengdu Brain Sci Inst;

    Univ Elect Sci &

    Technol China Ctr Informat Med MOE Key Lab Neuroinformat Chengdu Brain Sci Inst;

    Univ Elect Sci &

    Technol China Ctr Informat Med MOE Key Lab Neuroinformat Chengdu Brain Sci Inst;

    McGill Univ Montreal Neurol Inst McGill Ctr Integrat Neurosci Montreal PQ Canada;

    Univ Elect Sci &

    Technol China Ctr Informat Med MOE Key Lab Neuroinformat Chengdu Brain Sci Inst;

    Univ Elect Sci &

    Technol China Ctr Informat Med MOE Key Lab Neuroinformat Chengdu Brain Sci Inst;

    Univ Elect Sci &

    Technol China Ctr Informat Med MOE Key Lab Neuroinformat Chengdu Brain Sci Inst;

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  • 正文语种 eng
  • 中图分类 精神病学;
  • 关键词

    Schizophrenia; thalamus; functional connectivity; parcellation; tractography;

    机译：精神分裂症;丘脑;功能连接;局部;牵引;

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