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首页> 外文期刊>The British journal of psychiatry : >Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms
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Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms

机译：脑脊液Aandamide水平，大麻使用和精神病的症状

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摘要

Anandamide is a ligand of the endocannabinoid system. Animals show a depletion following repeated Δ9-tetrahydrocannabinol (THC) administration but the effect of cannabis use on central nervous system levels of endocannabinoids has not been previously examined in humans. Cerebrospinal fluid (CSF) levels of the endocannabinoids anandamide, 2-arachidonoylglycerol (2-AG) and related lipids were tested in 33 volunteers (20 cannabis users). Lower levels of CSF anandamide and higher levels of 2-AG in serum were observed in frequent compared with infrequent cannabis users. Levels of CSF anandamide were negatively correlated with persisting psychotic symptoms when drug-free. Higher levels of anandamide are associated with a lower risk of psychotic symptoms following cannabis use.
机译：Anandamide是Endocannabinoid系统的配体。 动物显示重复Δ9-四氢萘酚（THC）给药后耗尽，但是在人类中之前尚未检查大麻的效果对内突植物的中枢神经系统水平。 在33例志愿者（20大麻用户）中测试了脑骨烷醇，2- arachidonallgycerol（2-Ag）和相关脂质的脑脊液（CSF）水平。 与不经常的大麻用户相比，观察到频繁观察到血清中的较低水平的钙胺和血清中较高水平的2-Ag。 CSF Anandamide的CSF水平与无毒时与持续的精神症状负相关。 在大麻使用之后，较高水平的Anandamide与手术症状的风险较低。

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    MorganC.J.A.; PageE.; SchaeferC.; ChattenK.; ManochaA.; GulatiS.; CurranH.V.; BrandnerB.; LewekeF.M.;

  • 作者单位

    Clinical Psychopharmacology Unit University College London Gower St London WC1E 6BT United;

    Clinical Psychopharmacology Unit University College London Gower St London WC1E 6BT United;

    Department of Psychiatry and Psychotherapy Central Institute of Mental Health Heidelberg;

    Centre for Anaesthesia UCL Hospitals Trust London United Kingdom;

    Centre for Anaesthesia UCL Hospitals Trust London United Kingdom;

    Centre for Anaesthesia UCL Hospitals Trust London United Kingdom;

    Clinical Psychopharmacology Unit University College London Gower St London WC1E 6BT United;

    Centre for Anaesthesia UCL Hospitals Trust London United Kingdom;

    Department of Psychiatry and Psychotherapy Central Institute of Mental Health Heidelberg;

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  • 正文语种 eng
  • 中图分类 精神病学;
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