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首页> 外文期刊>The British journal of psychiatry : >Changes in prescribing for bipolar disorder between 2009 and 2016: national-level data linkage study in Scotland
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Changes in prescribing for bipolar disorder between 2009 and 2016: national-level data linkage study in Scotland

机译：2009年至2016年两国双相情感障碍规定的变化：苏格兰国家一级数据联系研究

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BackgroundPeople with bipolar disorder typically require long-term pharmacological treatment to prevent episodes of depression or mania. However, evidence-based guidelines are often not followed by prescribers and, in some countries, prescribing of lithium is in decline. Polypharmacy is also common in bipolar disorder.AimsTo employ a data linkage approach to describe and evaluate prescribing patterns in bipolar disorder in Scotland between 2009 and 2016.MethodBy linking prescribing data to the electronic Scottish Morbidity Records, we identified a cohort of 23 135 patients with bipolar disorder who were prescribed psychotropic medication between 2009 and 2016. We examined trends in proportions of patients prescribed each of six drug categories. Random effects logistic models examined change in prescribing over years of interest.ResultsThe most common form of treatment was antidepressant monotherapy (24.96%), with only 5.90% of patients receiving lithium monotherapy. Prescribing of antipsychotics and anti-epileptics increased from 2009 to 2016 (antipsychotics: odds ratio 1.16, 95% CI 1.15-1.18; anti-epileptics: odds ratio 1.34, 95% CI 1.32-1.36), whereas prescribing of lithium decreased (odds ratio 0.83, 95% CI 0.82-0.85). Prescribing of valproate decreased from 2009-2016 in women, but increased in men (women: odds ratio 0.93, 95% CI 0.90-0.97; men: odds ratio 1.11, 95% CI 1.04-1.18).ConclusionsAntidepressant monotherapy was the most common form of treatment for bipolar disorder in Scotland and prescribing of lithium has declined between 2009 and 2016. The findings are concerning and represent a gap between treatment guidelines and clinical practice.Declaration of interestNone.
机译：BackgroundPeple具有双相情感障碍通常需要长期药理治疗，以防止抑郁或躁狂发作。然而，基于证据的指导方针通常不会遵循公务员，并且在一些国家，锂的规定是下降。 PolyPharcacy在双极性疾病中也是常见的.aumsto采用数据联系方式，在2009年至2016年间苏格兰的双相障碍中描述和评估了对双相情感障碍的规定模式。接入对电子苏格兰发病率记录的方法，我们确定了23名135名135名患者的队列在2009年至2016年间处方的双相障碍是处方的精神药物。我们检查了每种六种药物类别的患者的比例的趋势。随机效应物流模型检查了多年兴趣的规定的变化。最常见的治疗形式是抗抑郁单药治疗（24.96％），只有5.90％的接受锂单一疗法的患者。抗精神病药和抗癫痫症的规定从2009年到2016年增加（抗精神病药：赔率比1.16,95％CI 1.15-1.18;抗癫痫药：差异比1.34,95％CI 1.32-1.36），而锂锂的规定减少（赔率0.83,95％CI 0.82-0.85）。 valproate的规定从2009 - 2016年减少了女性，但男性增加（女性：赔率比0.93,95％CI 0.90-0.97;男性：赔率比1.11,95％CI 1.04-1.18）.Conclionsantivements单疗法是最常见的形式2009年至2016年苏格兰双相障碍治疗与锂的规定下降。调查结果涉及治疗准则与临床实践之间的差距。

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