...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Cholinergic interneurons in the rat striatum modulate substitution of habits
【24h】

Cholinergic interneurons in the rat striatum modulate substitution of habits

机译：大鼠纹状体中的胆碱能Interneurons调节习惯的替代

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Behavioural flexibility is crucial for adaptive behaviour, and recent evidence suggests that cholinergic interneurons of the striatum play a distinct role. Previous studies of cholinergic function have focused on strategy switching by the dorsomedial or ventral striatum. We here investigated whether cholinergic interneurons in the dorsolateral striatum play a similar role at the level of switching of habitual responses. Because the dorsolateral striatum is particularly involved in habitual responding, we developed a habit substitution task that involved switching habitual leverpress responses to one side to another. We first measured the effect of cholinergic activation in the dorsolateral striatum on this task. Chemogenetic activation of cholinergic interneurons caused an increase in the response rate for the substituted response that was significantly greater than the increase normally seen in control animals. The increase was due to burstlike responses with shorter interpress intervals. However, there was no effect on inhibiting the old habit, or on habitual responding that did not require a switch. There was also no effect on leverpress performance and its reversal before leverpress responses became habitual. Conversely, neurochemically specific ablation of cholinergic interneurons did not significantly change habitual responding or response substitution. Thus, activation but not ablation of cholinergic interneurons in the dorsolateral striatum modulates expression of a new habit when an old habit is replaced by a new one. Together with previous work, this suggests that striatal cholinergic interneurons facilitate behavioural flexibility in both dorsolateral striatum in addition to dorsomedial and ventral striatum.
机译：摘要行为灵活性对于适应性行为至关重要，最近的证据表明纹章的胆碱能细胞间扮演着截然不同的作用。以前的胆碱能功能的研究专注于背侧或腹侧纹状体的策略。我们在这里研究了背侧纹状体中的胆碱能细胞是否在习惯性反应的转换水平上发挥了类似的作用。由于背侧纹状体尤其涉及习惯性的响应，因此我们开发了一种习惯替代任务，涉及将习惯性杠杆响应的习惯替代任务到另一方。我们首先测量了对这项任务背侧纹状体中的胆碱能激活的影响。胆碱能量间的化学激活导致替代响应的响应率的增加显着大于对照动物通常观察到的增加。增加的是由于缩短封闭间隔的突发响应。然而，对抑制旧习惯的影响没有影响，或者在习惯性的响应上，不需要交换机。在杠杆反应成为习惯性之前，对杠杆性能和逆转也没有影响。相反，神经化学的特异性杀灭胆碱能Interneurons没有显着改变习惯性响应或反应替代。因此，活化但不会消融背侧纹状体中的胆碱能细胞核算时调节新习惯的表达，当旧习惯被一个新的习惯所取代时。与以前的工作一起，这表明除了背侧和腹侧纹状体之外，纹状体胆碱能Interpeurons还促进了背侧纹状体中的行为灵活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号