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首页> 外文期刊>The European Journal of Neuroscience >Vascular and non-vascular contributors to memory reduction during traumatic brain injury
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Vascular and non-vascular contributors to memory reduction during traumatic brain injury

机译：在创伤性脑损伤期间对记忆降低的血管和非血管贡献者

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摘要

Traumatic brain injury (TBI) is an increasing health problem. It is a complex, progressive disease that consists of many factors affecting memory. Studies have shown that increased blood-brain barrier (BBB) permeability initiates pathological changes in neuro-vascular network but the role of cerebrovascular dysfunction and its mediated mechanisms associated with memory reduction during TBI are still not well understood. Changes in BBB, inflammation, extravasation of blood plasma components, activation of neuroglia lead to neurodegeneration. Extravasated proteins such as amyloid-beta, fibrinogen, and cellular prion protein may form degradation resistant complexes that can lead to neuronal dysfunction and degeneration. They also have the ability to activate astrocytes, and thus, can be involved in memory impairment. Understanding the triggering mechanisms and the places they originate in vasculature or in extravascular tissue may help to identify potential therapeutic targets to ameliorate memory reduction during TBI. The goal of this review is to discuss conceptual mechanisms that lead to short-term memory reduction during non-severe TBI considering distinction between vascular and non-vascular effects on neurons. Some aspects of these mechanisms need to be confirmed further. Therefore, we hope that the discussion presented bellow may lead to experiments that may clarify the triggering mechanisms of memory reduction after head trauma.
机译：创伤性脑损伤（TBI）是一种越来越大的健康问题。它是一种复杂，渐进的疾病，由影响记忆的许多因素组成。研究表明，增加的血脑屏障（BBB）渗透性引发神经血管网络的病理变化，但脑血管功能障碍的作用及其在TBI期间与记忆降低相关的介导机制仍然无法清楚地理解。 BBB的变化，炎症，血浆血浆组分，神经胶质细胞的激活导致神经变性。诸如淀粉样蛋白β，纤维蛋白原和细胞朊病毒蛋白的外向蛋白质可以形成可导致神经元功能障碍和变性的降解抗性复合物。它们还具有激活星形胶质细胞的能力，因此可以参与记忆障碍。理解触发机制和它们源自血管系统或血管内组织的地方可能有助于识别潜在的治疗靶标以在TBI期间改善记忆降低。本综述的目的是讨论在非严重TBI期间导致短期记忆降低的概念机制，考虑到血管和非血管作用对神经元的影响。需要进一步确认这些机制的一些方面。因此，我们希望展示波纹管道的讨论可能导致实验，这可以阐明头部创伤后记忆减少的触发机制。

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