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首页> 外文期刊>The European Journal of Neuroscience >FoxP expression identifies a Kenyon cell subtype in the honeybee mushroom bodies linking them to fruit fly αβc neurons
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FoxP expression identifies a Kenyon cell subtype in the honeybee mushroom bodies linking them to fruit fly αβc neurons

机译:FoxP表达鉴定了将它们连接到果蝇αβC神经元的蜜蜂蘑菇体中的kenyon细胞亚型

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摘要

The arthropod mushroom bodies (MB) are a higher order sensory integration centre. In insects, they play a central role in associative olfactory learning and memory. In Drosophila melanogaster (Dm), the highly ordered connectivity of heterogeneous MB neuron populations has been mapped using sophisticated molecular genetic and anatomical techniques. The MB-core subpopulation was recently shown to express the transcription factor FoxP with relevance for decision-making. Here, we report the development and adult distribution of a FoxP-expressing neuron population in the MB of honeybees (Apis mellifera, Am) using in situ hybridisation and a custom-made antiserum. We found the same expression pattern in adult bumblebees (Bombus terrestris, Bt). We also designed a new Dm transgenic line that reports FoxP transcriptional activity in the MB-core region, clarifying previously conflicting data of two other reporter lines. Considering developmental, anatomical and molecular similarities, our data are consistent with the concept of deep homology of FoxP expression in neuron populations coding reinforcement-based learning and habit formation.
机译:节肢动物蘑菇体(MB)是一个高阶感官集成中心。在昆虫中,他们在联合嗅觉学习和记忆中发挥着核心作用。在果蝇(DM)中,使用复杂的分子遗传学和解剖技术映射了异质MB神经元种群的高度有序连接。最近显示MB核亚群,表达转录因子Foxp,其具有决策的相关性。在这里,我们通过原位杂交和定制的抗血清向MB蜂窝状(APIS Mellifera,AM)中表达Foxp的神经元种群的开发和成人分布。我们在成人大黄蜂中发现了相同的表达模式(Bombus Terrestris,BT)。我们还设计了一种新的DM转基因系列,报告了MB核心区域中的Foxp转录活动,阐明了另外两条记者线的先前冲突的数据。考虑到发展,解剖学和分子异同,我们的数据与神经元群体中FoxP表达的深层同源性的概念一致,编码基于加强的学习和习惯形成。

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