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首页> 外文期刊>The European Journal of Neuroscience >Cross sex hormone treatment is linked with a reversal of cerebral patterns associated with gender dysphoria to the baseline of cisgender controls
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Cross sex hormone treatment is linked with a reversal of cerebral patterns associated with gender dysphoria to the baseline of cisgender controls

机译：交叉性激素治疗与与性别困难相关的脑模式的逆转有关，与Cisbender对照组的基线相关联

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摘要

Transgender persons experience incongruence between their gender identity and birth-assigned sex. The resulting gender dysphoria (GD), is frequently treated with cross-sex hormones. However, very little is known about how this treatment affects the brain of individuals with GD, nor do we know the neurobiology of GD. We recently suggested that disconnection of fronto-parietal networks involved in own-body self-referential processing could be a plausible mechanism, and that the anatomical correlate could be a thickening of the mesial prefrontal and precuneus cortex, which is unrelated to sex. Here, we investigate how cross-sex hormone treatment affects cerebral tissue in persons with GD, and how potential changes are related to self-body perception. Longitudinal MRI measurements of cortical thickness (Cth) were carried out in 40 transgender men (TrM), 24 transgender women (TrW) and 19 controls. Cth increased in the mesial temporal and insular cortices with testosterone treatment in TrM, whereas anti-androgen and oestrogen treatment in TrW caused widespread cortical thinning. However, after correction for treatment-related changes in total grey and white matter volumes (increase with testosterone; decrease with anti-androgen and oestrogen), significant Cth decreases were observed in the mesial prefrontal and parietal cortices, in both TrM and TrW (vs. controls) - regions showing greater pre-treatment Cth than in controls. The own body - self congruence ratings increased with treatment, and correlated with a left parietal cortical thinning. These data confirm our hypothesis that GD may be associated with specific anatomical features in own-body/self-processing circuits that reverse to the pattern of cisgender controls after cross-sex hormone treatment.
机译：跨候人士在其性别认同和出生分配性之间存在不一致。由此产生的性别痉挛（GD）经常用交叉性激素治疗。然而，关于这种治疗如何影响人物的大脑，甚至很少，也不知道我们也不知道GD的神经生物学。我们最近建议断开涉及自己的身体自我参照处理的前景网络可以是一种合理的机制，并且解剖学相关性可能是歧视前额框形和PREICEUS皮质的增厚，这与性不相关。在这里，我们调查交叉性激素治疗如何对GD的人物影响脑组织，以及潜在的变化与自身人体感知有何相关。皮质厚度（CTH）的纵向MRI测量在40例变性男性（TRM），24例转型女性（TRW）和19个对照中进行。在TRM中的睾丸激素治疗中，CTH在弱小的颞延迟皮质中增加，而TRW中的抗雄激素和雌激素治疗引起了广泛的皮质稀释。然而，在校正灰色和白质量体积的治疗相关变化后（随着睾酮增加;随着抗雄激素和雌激素的增加），在TRM和TRW中，在弱弦前额叶和椎管内皮质中观察到显着的CTH降低（VS 。控制） - 显示比对照的更高预处理的区域。自身的身体 - 自我同时评分随治疗而增加，与左侧皮质稀疏相关。这些数据证实了我们的假设，即GD可以与自己的身体/自处理电路中的特定解剖特征相关联，其在交叉性激素治疗后逆转到Cisgender对照的模式。

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