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首页> 外文期刊>The European Journal of Neuroscience >A neuroscience perspective of the gut theory of Parkinson's disease
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A neuroscience perspective of the gut theory of Parkinson's disease

机译：帕金森病肠道理论的神经科学观点

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摘要

Abstract Parkinson's disease is caused by complex interactions between environmental factors and a genetic predisposition. Environmental factors include exposure to pesticides and toxins, heavy metals and accumulation of iron and/or manganese in the brain. However, accumulating evidence indicates that gut–brain health and function are impaired in Parkinson's disease, often a decade before motor symptoms are diagnosed. We present the gut–brain theory of Parkinson's disease and summarise the peripheral and central nervous system pathology, gastrointestinal symptoms experienced by many Parkinson's patients, the route by which gut–brain dysfunction may occur and changes in gut microbiota that are associated with disease expression. Finally, we consider future gut‐based treatments to prevent or slow down the progression of Parkinson's disease and explore whether this knowledge may highlight biomarkers to be included in complex algorithms in the future to assess a person's risk of developing Parkinson's disease.
机译：摘要帕金森病是由环境因素与遗传易感性之间复杂的相互作用引起的。环境因素包括暴露于农药和毒素，重金属和脑内铁和/或锰的积累。然而，积累证据表明帕金森病的肠道脑部健康和功能受损，通常在诊断运动症状之前十年。我们展示了帕金森病的肠道脑理论，总结了许多帕金森病人所经历的外周血和中枢神经系统病理学，肠道功能障碍可能发生的途径和与疾病表达相关的肠道微生物症的途径。最后，我们考虑未来的肠道治疗，以防止或减缓帕金森病的进展，并探讨了这些知识是否可以突出未来在复杂的算法中突出的生物标志物，以评估一个人发展帕金森病的风险。

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