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首页> 外文期刊>The European Journal of Neuroscience >Different output properties of perisomatic region‐targeting interneurons in the basal amygdala
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Different output properties of perisomatic region‐targeting interneurons in the basal amygdala

机译：基底杏仁塔中侧无族地区靶向间的不同输出特性

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Abstract The perisomatic region of principal neurons in cortical regions is innervated by three types ofGABA ergic interneuron, including parvalbumincontaining basket cells (PVBC s) and axoaxonic cells (AAC s), as well as cholecystokinin and type 1 cannabinoid receptorexpressing basket cells (CCK /CB 1BC s). These perisomatic inhibitory cell types can also be found in the basal nucleus of the amygdala, however, their output properties are largely unknown. Here, we performed wholecell recordings in morphologically identified interneurons in slices prepared from transgenic mice, in which theGABA ergic cells could be selectively targeted. Investigating the passive and active membrane properties of interneurons located within the basal amygdala revealed that the three interneuron types have distinct singlecell properties. For instance, the input resistance, spike rate, accommodation in discharge rate, or afterhyperpolarization width at the half maximal amplitude separated the three interneuron types. Furthermore, we performed paired recordings from interneurons and principal neurons to uncover the basic features of unitary inhibitory postsynaptic currents (uIPSC s). Although we found no difference in the magnitude of responses measured in the principal neurons, theuIPSC s originating from the distinct interneuron types differed in rise time, failure rate, latency, and shortterm dynamics. Moreover, the asynchronous transmitter release induced by a train of action potentials was typical for the output synapses ofCCK /CB 1BC s. Our results suggest that, despite the similaruIPSC magnitudes originating from the three perisomatic inhibitory cell types, their distinct release properties together with the marked differences in their spiking characteristics may contribute to accomplish specific functions in amygdala network operation.
机译：摘要皮质区域中主要神经元的象鼻区域被三种类型的胶囊中间核，包括Parvalbumincumintaining篮子细胞（PVBC S）和腋xCOL（AAC S），以及胆囊蛋白和1型大麻素接受抑制篮细胞（CCK / CB 1BC S）。这些漂白的抑制细胞类型也可以在杏仁达拉的基础核中发现，然而，它们的产出性质主要是未知的。在这里，我们在由转基因小鼠制备的切片中的形态学鉴定的中间核中的形态鉴定的κόκ族，其中可以选择性地靶向。调查位于基底杏仁达拉内的中间核的被动和活性膜特性显示，三种中间核苷酸具有不同的单晶片性质。例如，半最大幅度下的输入电阻，尖峰率，放电速度的容纳或后胚宽度分开了三种中间型类型。此外，我们从内核和主要神经元进行了配对的录制，以揭示单一禁止突触突触电流的基本特征（UIPSC S）。虽然我们发现在主神经元中测量的响应幅度没有差异，但是源自不同的中间核素类型的uIPSc s在上升时间，故障率，延迟和短期动态中不同。此外，由动作电位列车引起的异步发射器释放对于OFCCK / CB 1BC S的输出突触典型是典型的。我们的研究结果表明，尽管源自三种横向抑制细胞类型的类似尺寸，但它们的不同释放特性与其尖峰特性的显着差异可能有助于实现Amygdala网络操作中的特定功能。

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