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首页> 外文期刊>The European Journal of Neuroscience >Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages?
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Is the dopaminergic loss associated with gait and postural impairments in subjects with Parkinson's disease at different motor stages?

机译：是与不同电机阶段的帕金森病的科目的步态和姿势损伤相关的多巴胺能损失？

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摘要

Gait and postural control deficiencies in Parkinson's disease (PD) involve several specific motor aspects. The aim of this study was to identify and compare the main changes in gait kinematics and postural control with dopaminergic loss in the striatum region. This is a cross-sectional study that included 42 individuals with PD at different motor stages, according to the Hoehn & Yahr scale (H&Y). Motor subsection of the Movement Disorder Society-Unified Parkinson Disease Rating Scale-part III (MDS-UPDRS III) was used to evaluate general motor aspects. Gait kinematics was assessed using a three-dimensional motion capture system. Postural control was assessed by stabilometry using force platforms. Dopamine depletion was verified through 99mTc-TRODAT-1 (SPECT-CT) examination. We included 12, 15 and 15 individuals classified as H&Y I, II and III, respectively. We identified worse values of dopamine transporter uptake, MDS-UPDRS III, gait parameters (velocity, step length and stride length) and center of pressure displacement as the disease progressed. Our results indicate that higher dopaminergic loss and gait and postural control deficits occur between the H&Y levels II and III.
机译：帕金森病（PD）的步态和姿势控制缺陷涉及几个特定的​​电机方面。本研究的目的是识别和比较步态运动学的主要变化和纹状体区域中的多巴胺能损失和姿势控制。这是一个横截面研究，包括由Hoehn＆Yahr Scale（H＆Y）的不同电机阶段的42个具有PD的个体。运动障碍协会 - 统一帕金森病评级尺度III（MDS-UPDRS III）的电机划分用于评估一般电机方面。使用三维运动捕获系统评估步态运动学。使用力平台通过稳定测定评估姿势对照。通过99MTC-TRODAT-1（SPECT-CT）检查验证了多巴胺枯萎病。我们分别包括12,15和15名分类为H＆Y I，II和III的个人。我们确定了多巴胺转运蛋白摄取，MDS-UPDRI III，步态参数（速度，步长和步幅长度）和压力位移中心的更差异。我们的结果表明，H＆Y水平II和III之间发生了更高的多巴胺能损失和步态和姿势控制缺陷。

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