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首页> 外文期刊>The European Journal of Neuroscience >Neuronal oscillations on an ultra‐slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork
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Neuronal oscillations on an ultra‐slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork

机译：超慢时间尺度的神经元振荡：哺乳动物昼夜昼夜昼夜节奏中的电活动和基因表达中的每日节律

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Abstract Neuronal oscillations of the brain, such as those observed in the cortices and hippocampi of behaving animals and humans, span across wide frequency bands, from slow delta waves (0.1?Hz) to ultra‐fast ripples (600?Hz). Here, we focus on ultra‐slow neuronal oscillators in the hypothalamic suprachiasmatic nuclei ( SCN ), the master daily clock that operates on interlocking transcription‐translation feedback loops to produce circadian rhythms in clock gene expression with a period of near 24?h (?0.001?Hz). This intracellular molecular clock interacts with the cell's membrane through poorly understood mechanisms to drive the daily pattern in the electrical excitability of SCN neurons, exhibiting an up‐state during the day and a down‐state at night. In turn, the membrane activity feeds back to regulate the oscillatory activity of clock gene programs. In this review, we emphasise the circadian processes that drive daily electrical oscillations in SCN neurons, and highlight how mathematical modelling contributes to our increasing understanding of circadian rhythm generation, synchronisation and communication within this hypothalamic region and across other brain circuits.
机译：摘要大脑的神经元振荡，例如在皮质和人类和人类的皮质和海马观察到的那些，跨越宽频带，从缓慢的δ波（0.1？Hz）到超快速涟漪（600？Hz）。在这里，我们专注于下丘脑的超慢神经元振荡器（SCN），主日间在互锁转录转换反馈环上运行，以在时钟基因表达中产生昼夜节律，在近24Ω·H（＆ ;？0.001？Hz）。这种细胞内分子时钟通过理解的机制与细胞的膜相互作用，以驱动SCN神经元的电兴奋性的日常模式，在白天在夜间展示上升状态和下降状态。反过来，膜活性送回调节时钟基因计划的振荡活动。在这篇综述中，我们强调了在SCN神经元中推动日常电振荡的昼夜节约过程，并突出了数学建模如何如何促进对该下丘脑区域内的昼夜节律生成，同步和通信的越来越高兴。

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