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首页> 外文期刊>The European Journal of Neuroscience >Long-lasting modifications of motoneuron firing properties by trans-spinal direct current stimulation in rats
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Long-lasting modifications of motoneuron firing properties by trans-spinal direct current stimulation in rats

机译：大鼠跨脊柱直流刺激的Motoneuron烧制性能的长期修饰

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Trans-spinal direct current stimulation (tsDCS) is a novel neuromodulatory technique that has been used during neurological rehabilitation and sports to modulate muscle activation. However, the physiological mechanisms that underly the long-lasting functional effects of polarization are not yet fully understood, nor are their relationships with specific neuronal populations. The acute facilitatory and depressive effects of anodal and cathodal polarization on motoneurons have been recently demonstrated, and the aim of this study was to determine whether tsDCS-evoked modulations of motoneuron properties are able to persist over several hours. Intracellular recordings from multiple antidromically identified rat motoneurons were performed both before and after the application of tsDCS (0.1 mA for 15 min), at various time points up to 180 min after the offset of anodal or cathodal tsDCS. The examined effects of anodal polarization included decreased rheobase, voltage threshold, the minimum and maximum currents necessary for rhythmic firing, increased rhythmic firing frequencies and the slope of the f-I relationship. The majority of these facilitatory changes to threshold and firing properties were sustained for 30-60 min after polarization. In contrast, the significant effects of cathodal polarization were absent, except the short-lasting decreased ability for motoneurons to induce rhythmic activity. This study provides direct evidence that a single polarization session can alter the electrophysiological properties of motoneurons for at least one hour and provides a basis for the further use of tsDCS techniques under conditions where the sustained modification of motoneuron firing is desired.
机译：跨脊柱直流刺激（TSDC）是一种新型神经调节技术，其在神经系统康复和运动过程中用于调节肌肉激活。然而，尚未完全理解差异持久的常态效果的生理机制，也不是它们与特定神经元群的关系。最近已经证明了嗜阳性和阴极极化对运动神经元的急性促进和抑郁效应，并且该研究的目的是确定TSDCS诱发的Motoneuron性能调节是否能够持续几个小时。在施用TSDCS（0.1 mA持续15分钟）之前和之后，在阳极或阴极TSDCS偏移后的各个时间点，在施用TSDCS（0.1 mA持续15分钟）之前和之后进行多次抗型鉴定的大鼠运动神经元的细胞内记录。阳极偏振的检查效果包括降低的流碱基，电压阈值，节奏烧制所需的最小和最大电流，增加节奏烧制频率和F-I关系的斜率。大部分促进变化对阈值和烧制性能的变化在极化后持续30-60分钟。相比之下，除了诱导节奏活性的短暂持久性降低之外，阴极偏振的显着效果不存在。该研究提供了直接证据，即单个偏振会期可以改变运动神经元的电生理学性能至少一小时，并为需要在需要持续修饰的条件下进一步使用TSDC技术的基础。

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