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首页> 外文期刊>The European Journal of Neuroscience >Contrast gain control and retinogeniculate communication
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Contrast gain control and retinogeniculate communication

机译：对比度增益控制和视源性通信

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Abstract Visual information processed in the retina is transmitted to primary visual cortex via relay cells in the lateral geniculate nucleus ( LGN ) of the dorsal thalamus. Although retinal ganglion cells are the primary source of driving input to LGN neurons, not all retinal spikes are transmitted to the cortex. Here, we investigate the relationship between stimulus contrast and retinogeniculate communication and test the hypothesis that both the time course and strength of retinogeniculate interactions are dynamic and dependent on stimulus contrast. By simultaneously recording the spiking activity of synaptically connected retinal ganglion cells and LGN neurons in the cat, we show that the temporal window for retinogeniculate integration and the effectiveness of individual retinal spikes are inversely proportional to stimulus contrast. This finding provides a mechanistic understanding for the phenomenon of augmented contrast gain control in the LGN —a nonlinear receptive field property of LGN neurons whereby response gain during low‐contrast stimulation is enhanced relative to response gain during high‐contrast stimulation. In addition, these results support the view that network interactions beyond the retina play an essential role in transforming visual signals en route from retina to cortex.
机译：摘要在视网膜中处理的视觉信息通过背部丘脑的横向遗传细胞核（LGN）中的继电器细胞传递给初级视觉皮质。虽然视网膜神经节细胞是驱动输入到LGN神经元的主要源，但并非所有视网膜钉都传递到皮质。在这里，我们研究了刺激对比度与视源性传播之间的关系，并测试了视源性相互作用的时间和强度是动态的，依赖于刺激对比度。通过在猫中同时记录突触连接的视网膜神经节细胞和LGN神经元的尖刺活动，我们表明用于转源性整合的时间窗口和单个视网膜尖峰的有效性与刺激对比度成反比。该发现提供了对LGN神经元的LGN -A非线性接收场特性的增强对比度增益控制现象的机械理解，从而相对于高对比度刺激期间的响应增益增强了低对比度刺激期间的响应增益。此外，这些结果支持视网膜超出视网膜的网络相互作用在转换从Retina到皮质的路线转换的基本作用。

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