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首页> 外文期刊>The European Journal of Neuroscience >Activation of galanin and cholecystokinin receptors in the lumbosacral spinal cord is required for ejaculation in male rats
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Activation of galanin and cholecystokinin receptors in the lumbosacral spinal cord is required for ejaculation in male rats

机译：雄性大鼠射精需要在腰骶部脊髓中的环肽和胆囊蛋白受体的活化

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Abstract The spinal ejaculation generator is comprised of lumbar spinothalamic (LS t) cells and their axonal projections to autonomic and motor neurons in the lumbosacral spinal cord.LS t cells regulate ejaculatory reflexes by release of neuropeptides that are coexpressed in their axons, as previously demonstrated for gastrinreleasing peptide and enkephalin. Here, the role of two other neuropeptides coexpressed inLS t cells for ejaculatory reflexes is demonstrated: galanin and cholecystokinin (CCK ). Adult male rats were anesthetized, spinalized, and received intrathecal infusions of galanin receptor antagonist Galantide (1 or 10爊mol) orCCK receptor antagonist proglumide (71 or 714爊mol). The dorsal penile nerve (DPN ) was electrically stimulated to trigger ejaculatory reflexes and seminal vesicle pressure (SVP ) and rhythmic contractions of the bulbocavernosus muscle (BCM ) were analyzed as parameters of emission and expulsion respectively. Treatment with galanin orCCK antagonists significantly reducedSVP increases andBCM bursting, demonstrating that galanin andCCK are required for ejaculation. Next, anesthetized, spinalized males received intrathecal infusions of galanin (0.15 or 0.3爊mol) orCCK (2633) (4.35爊mol) and effects on subthresholdDPN stimulations were determined. Intrathecal infusions of galanin orCCK facilitated ejaculatory reflexes induced by subthresholdDPN stimulation in all animals, but did not trigger ejaculatory reflexes in the absence ofDPN stimulation. Together, these results demonstrate that galanin andCCK both act in the spinal ejaculation generator to regulate ejaculation. However, effects of galanin andCCK were dependent onDPN stimulation, suggesting that these neuropeptides may act in concert with otherLS t coexpressed neuropeptides.
机译：摘要脊髓射精发生器由腰椎肌醇（LS T）细胞组成，并且它们在腰骶部脊髓中的自主主义和运动神经元组成。当前证明用于胃泌素肽和Enkephalin。这里，对另外两种神经肽的共同反应的两个肽的InLS T细胞的作用进行了说明：Galanin和胆囊蛋白（CCK）。将成年雄性大鼠麻醉，脊髓化，并接受环肽受体拮抗剂Galantide（1或10μmmol）Orcck受体拮抗剂翻译（71或714摩尔）的鞘内输注。将背侧阴茎神经（DPN）电刺激以触发射精反射，分别分别分析膨胀肌肌肉（BCM）的精囊压力（SVP）和节奏收缩分别作为发射和排出的参数。含环蛋白Orcck拮抗剂的治疗显着降低了ANDBCM爆裂，表明射精需要环肽和晶圆。接下来，麻醉的脊髓化雄性受到环烷（0.15或0.3μmmol）Orcck（2633）（4.35摩尔）的鞘内输注，并测定对亚阈值DPN刺激的影响。在所有动物中，在所有动物中诱导的植物植入植物的鞘内输注促进了由亚阈值DPN刺激引起的eJaculatory反射，但在不存在OFDPN刺激的情况下没有引发射精反射。这些结果一起表明，环丙蛋白和晶体在脊髓射精发生器中起作用以调节射精。然而，甘醇蛋白和曲线的影响依赖于DondPN刺激，表明这些神经肽可以与其他组成的神经肽一起用职能作用。

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