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首页> 外文期刊>The European Journal of Neuroscience >Circadian rhythm of redox state regulates membrane excitability in hippocampal CA1 neurons
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Circadian rhythm of redox state regulates membrane excitability in hippocampal CA1 neurons

机译：氧化还原状态的昼夜节律调节海马CA1神经元的膜兴奋性

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摘要

Behaviors, such as sleeping, foraging, and learning, are controlled by different regions of the rat brain, yet they occur rhythmically over the course of day and night. They are aligned adaptively with the day-night cycle by an endogenous circadian clock in the suprachiasmatic nucleus (SCN), but local mechanisms of rhythmic control are not established. The SCN expresses a 24-hr oscillation in reduction-oxidation that modulates its own neuronal excitability. Could circadian redox oscillations control neuronal excitability elsewhere in the brain? We focused on the CA1 region of the rat hippocampus, which is known for integrating information as memories and where clock gene expression undergoes a circadian oscillation that is in anti-phase to the SCN. Evaluating long-term imaging of endogenous redox couples and biochemical determination of glutathiolation levels, we observed oscillations with a 24 hr period that is 180 degrees out-of-phase to the SCN. Excitability of CA1 pyramidal neurons, primary hippocampal projection neurons, also exhibits a rhythm in resting membrane potential that is circadian time-dependent and opposite from that of the SCN. The reducing reagent glutathione rapidly and reversibly depolarized the resting membrane potential of CA1 neurons; the magnitude is time-of-day-dependent and, again, opposite from the SCN. These findings extend circadian redox regulation of neuronal excitability from the SCN to the hippocampus. Insights into this system contribute to understanding hippocampal circadian processes, such as learning and memory, seizure susceptibility, and memory loss with aging.
机译：行为，例如睡觉，觅食和学习，由大鼠大脑的不同区域控制，但它们在一天和夜间的过程中有节奏地发生。它们通过在Suprachiasmatic核（SCN）中的内源性昼夜昼夜自适应地对齐日夜循环，但没有建立节奏控制的局部机制。 SCN表达了在还原氧化中的24小时振荡，以调节其自身的神经元兴奋性。 Circadian Redox振荡可以控制大脑的其他地方的神经元刺激性吗？我们专注于大鼠海马的Ca1区，已知用于将信息作为存储器集成，而时钟基因表达经历昼夜振荡，则抗阶段抗阶段。评估内源性氧化还原的长期成像和谷胱甘肽水平的生物化学测定，观察​​到24小时的振荡，24小时的时间为180度到SCN。 Ca1金字塔神经元，原发性海马投影神经元的兴奋性也表现出静止膜电位的节奏，该节奏是昼夜依赖于SCN的昼夜时间和对面。还原剂谷胱甘肽快速且可逆地去极化了Ca1神经元的静止膜电位;幅度是依赖于时期的，再次与SCN相反。这些发现将昼夜神经元兴奋性延伸到海马的神经元兴奋性。该系统的见解有助于了解海马昼夜活动，例如学习和记忆，癫痫发作和随老化的记忆损失。

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