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首页> 外文期刊>The European Journal of Neuroscience >'Hot' vs. 'cold' behavioural-cognitive styles: motivational-dopaminergic vs. cognitive-cholinergic processing of a Pavlovian cocaine cue in sign- and goal-tracking rats
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'Hot' vs. 'cold' behavioural-cognitive styles: motivational-dopaminergic vs. cognitive-cholinergic processing of a Pavlovian cocaine cue in sign- and goal-tracking rats

机译：'热'与'冷'行为 - 认知风格：致动 - 多巴胺能与帕夫洛维亚可卡因的认知 - 胆碱能加工在签名和目标跟踪大鼠

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Discrete Pavlovian reward cues acquire more potent incentive motivational properties (incentive salience) in some animals (sign-trackers; STs) compared to others (goal-trackers; GTs). Conversely, GTs appear to be better than STs in processing more complex contextual cues, perhaps reflecting their relatively greater bias for goal-directed cue processing. Here, we investigated the activity of two major prefrontal neuromodulatory input systems, dopamine (DA) and acetylcholine (ACh), in response to a discrete Pavlovian cue that was previously paired with cocaine administration in STs and GTs. Rats underwent Pavlovian training in which light cue presentations were either paired or unpaired with an intravenous cocaine infusion. Following a 10-day abstinence period, prefrontal dialysates were collected in STs and GTs during cue presentations in the absence of cocaine. In STs, the cue previously paired with cocaine significantly increased prefrontal DA levels. DA levels remained elevated over baseline across multiple cue presentation blocks, and DA levels and approaches to the cue were significantly correlated. In STs, ACh levels were unaffected by cue presentations. In contrast, in GTs, presentations of the cocaine cue increased prefrontal ACh, but not DA, levels. GTs oriented towards the cue at rates similar to STs, but they did not approach it and elevated ACh levels did not correlate with conditioned orientation. The results indicate a double dissociation between the role of prefrontal DA and ACh in STs and GTs, and suggest that these phenotypes will be useful for studying the role of neuromodulator systems in mediating opponent behavioural-cognitive styles.
机译：离散的Pavlovian奖励提示在与他人（目标跟踪器; GTS）相比，在某些动物（标志跟踪器; STS）中获得了更有效的激励动机性质（激励促销）。相反，GTS在处理更复杂的上下文提示时，GTS似乎更好，也许反映了他们对目标定向提示处理的相对更大的偏差。在这里，我们研究了两个主要前额相神经调节输入系统，多巴胺（DA）和乙酰胆碱（ACH）的活性，以响应于先前与STS和GTS中的可卡因管理配对的离散帕夫洛韦提示。大鼠接受了Pavlovian培训，其中光线介绍是用静脉内可卡因输注配对或未配对。在禁因期10天后，在没有可卡因的情况下，在提示介绍期间在STS和GTS中收集预前透析液。在STS中，提示先前与可卡因配对显着增加了预前期DA水平。在多个提示呈现块中，DA水平仍然在基线上升高，并且DA水平和提示方法显着相关。在STS，ACH水平不受影响介绍的影响。相比之下，在GTS中，可卡因提示的介绍增加了预期ACH，但不是DA，水平。 GTS以与STS相似的速率向提示，但它们没有接近它，升高的ACH水平与条件取向没有相关。结果表明前额叶DA和ACH在STS和GTS中的作用之间的双重解剖，并表明这些表型可用于研究神经调节系统在调解对手行为认知风格中的作用。

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