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首页> 外文期刊>The European Journal of Neuroscience >Sex matters: females in proestrus show greater diazepam anxiolysis and brain‐derived neurotrophin factor‐ and parvalbumin‐positive neurons than males
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Sex matters: females in proestrus show greater diazepam anxiolysis and brain‐derived neurotrophin factor‐ and parvalbumin‐positive neurons than males

机译：性问题：prestrus的女性显示出更大的乳头焦虑和脑源性神经营养蛋白因子和蛋白含蛋白阳性神经元

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Abstract In humans and animal models, sex differences are reported for anxietylike behavior and response to anxiogenic stimuli. In the current work, we studied anxietylike behavior and response to the prototypical antianxiety drug, diazepam. We used 6th generation outbred lines of adult Long Evans rats with high and low anxietylike behavior phenotypes to investigate the impact of proestrus on the baseline and diazepaminduced behavior. At three doses of diazepam (0, 0.1, and 1.0 g/kg, i.p.), we measured anxiogenic responses on the elevated plus maze of adult male and female rats. We assessed parvalbumin and brainderived neurotrophin protein levels in forebrain and limbic structures implicated in anxiety/stress using immunohistochemistry. At baseline, we saw significant differences between anxiety lines, with high anxiety lines displaying less time on the open arms of the elevated plus maze, and less open arm entries, regardless of sex. During proestrus, high anxiety females showed less anxietylike behavior at 0.1 g/kg, while low anxiety females displayed less anxietylike behavior at 0.1 and 1.0 doses, relative to males. Brainderived neurotrophin protein was elevated in females in the medial prefrontal cortex and central amygdala, while parvalbuminimmunoreactive cells were greater in males in the medial prefrontal cortex. Parvalbuminpositive cells in high anxiety females were higher inCA 2 and dentate gyrus relative to males from the same line. In sum, when tested in proestrus, females showed greater anxiolytic effects of diazepam relative to males, and this correlated with increases in neurotrophin and parvalbumin neuron density in corticolimbic structures.
机译：摘要在人类和动物模型中，据报道了性差异为焦虑的行为和对焦虑刺激的反应。在目前的工作中，我们研究了焦虑的行为和对原型抗令人令人惊叹的药物，Diazepam的反应。我们使用了成人长埃文斯大鼠的第6阶代郊区，具有高低焦虑的行为表型，探讨了ProAstrus对基线和结膜异己酸的影响。在三剂量的二聚醇泮（0,0.1和1.0g / kg，I.P）中，我们测量了对成年男性和雌性大鼠的升高的迷宫的焦虑反应。我们评估了前脑中的帕瓦耳蛋白和脑卒中的神经营养蛋白蛋白水平和使用免疫组织化学涉及焦虑/胁迫的肢体结构。在基线时，我们在焦虑线之间看到了显着的差异，高焦虑线在升高的加迷宫的张开臂​​上显示较少的时间，而不管性别如何，较少的开放式臂章。在Proastrus期间，高焦虑女性在0.1g / kg时表现出较少的焦虑行为，而相对于男性，低焦虑女性在0.1和1.0剂量下显示出较少的焦虑行为。在内侧前额叶皮质和中央杏仁酵母中雌性肾上腺素蛋白升高了脑膜的神经营养蛋白蛋白，而中间前额叶皮质中的雄性蛋白酶免疫反应性细胞较大。高焦虑女性中的帕拉巴蛋白聚合物细胞较高的印加2和牙齿相对于来自同一条线的雄性的牙齿回归。总而言之，当在Proastrus测试时，女性表现出相对于雄性的Diazepam的更大抗焦虑作用，并且这种与心肌蛋白结构中的神经营养蛋白和帕瓦仑神经元密度的增加相关。

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