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首页> 外文期刊>The European Journal of Neuroscience >Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function
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Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function

机译：父亲暴露于滥用行为和神经功能滥用药物的多杀和转基因影响

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摘要

Addictions are highly heritable disorders, with heritability estimates ranging from 39% to 72%. Multiple studies suggest a link between paternal drug abuse and addiction in their children. However, patterns of inheritance cannot be explained purely by Mendelian genetic mechanisms. Exposure to drugs of abuse results in epigenetic changes that may be passed on through the germline. This mechanism of epigenetic transgenerational inheritance may provide a link between paternal drug exposure and addiction susceptibility in the offspring. Recent studies have begun to investigate the effect of paternal drug exposure on behavioral and neurobiological phenotypes in offspring of drug-exposed fathers in rodent models. This review aims to discuss behavioral and neural effects of paternal exposure to alcohol, cocaine, opioids, and nicotine. Although a special focus will be on addiction-relevant behaviors, additional behavioral effects including cognition, anxiety, and depressive-like behaviors will be discussed.
机译：成瘾是一种高度遗传的障碍，可遗传性估计范围从39％到72％。多项研究表明，他们儿童患者滥用和成瘾之间的联系。然而，孟德尔遗传机制纯粹不能解释遗传模式。暴露于滥用药物导致可以通过种系通过的表观遗传变化。这种表观遗传转基因遗传机制可以提供在后代父毒暴露和成瘾之间的联系。最近的研究已经开始探讨父毒暴露对啮齿动物模型中药物暴露父亲后代行为和神经生物学表型的影响。该审查旨在讨论父系暴露于酒精，可卡因，阿片类药物和尼古丁的行为和神经效应。虽然特别焦点将是成瘾相关行为，但讨论了包括认知，焦虑和抑郁行为的额外行为效应。

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