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首页> 外文期刊>The European Journal of Neuroscience >The strengths of the genetic approach to understanding neural systems development and function: Ray Guillery's synthesis
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The strengths of the genetic approach to understanding neural systems development and function: Ray Guillery's synthesis

机译:理解神经系统发展和功能的遗传方法的优势:Ray Puillery的合成

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ABSTRACT: The organization and function of sensory systems, especially the mammalian visual system, has been the focus of philosophers and scientists for centuries—from Descartes and Newton onward. Nevertheless, the utility of understanding development and its genetic foundations for deeper insight into neural function has been debated: Do you need to know how something is assembled—a car, for example—to understand how it works or how to use it—to turn on the ignition and drive? This review addresses this issue for sensory pathways. The pioneering work of the late Rainer W. (Ray) Guillery provides an unequivocal answer to this central question: Using genetics for mechanistic exploration of sensory system development yields essential knowledge of organization and function. Ray truly built the foundation for this now accepted tenet of modern neuroscience. His work on the development and reorganization of visual pathways in albino mammals—all with primary genetic mutations in genes for pigmentation—defined the genetic approach to neural systems development, function and plasticity. The work that followed his lead in a variety of sensory systems, including my own work in the developing olfactory system, proceeds directly from Ray's fundamental contributions. ? 2018 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
机译:摘要:感官系统的组织和功能,特别是哺乳动物视觉系统,一直是哲学家和科学家的焦点 - 从笛卡尔和牛顿开始。尽管如此,理解发展及其对神经功能深入了解的遗传基础已经讨论了:您是否需要知道如何组装一些汽车 - 例如 - 了解它是如何运作的或如何使用它 - 转向在点火和驱动器上?此评论为感官途径填写此问题。晚雨淋W.(Ray)突出的开创性工作为这一核心问题提供了明确的答案:利用遗传学对感官系统的机械探索产生的组织和功能的基本知识。 Ray真正为此建造了这个基础,现在接受了现代神经科学的宗旨。他对白化哺乳动物的视觉途径的发展和重组 - 均具有基因的初级遗传突变进行色素沉着的灭绝 - 定义了神经系统发育,功能和可塑性的遗传方法。在各种感官系统中遵循其领先的工作,包括我在开发嗅觉系统中的工作,直接从Ray的基本贡献进行。还2018年作者。欧洲神经科学协会联合会发表的欧洲神经科学杂志和约翰瓦里&儿子有限公司

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