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首页> 外文期刊>The European Journal of Neuroscience >Activation of the neural pathway from the dorsolateral bed nucleus of the stria terminalis to the central amygdala induces anxiety-like behaviors
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Activation of the neural pathway from the dorsolateral bed nucleus of the stria terminalis to the central amygdala induces anxiety-like behaviors

机译：从斯特拉氏菌的背侧床核激活神经途径到中央杏仁核诱导焦虑的行为

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The bed nucleus of the stria terminalis (BNST) and the central amygdala (CeA) comprise a forebrain unit that has been described as the extended amygdala. These two nuclei send dense projections to each other and have been implicated in the regulation of negative emotional states, including anxiety and fear. The present study employed an optogenetic technique to examine whether stimulation of CeA-projecting dorsolateral BNST (dlBNST) neuron terminals would influence anxiety-like behaviors in male Sprague-Dawley rats. Photostimulation of CeA-projecting dlBNST neuron terminals produced anxiogenic effects in an elevated plus maze test. This finding is inconsistent with previous reports showing that optogenetic stimulation of BNST neurons projecting to the lateral hypothalamus (LH) and ventral tegmental area (VTA) produces anxiolytic rather than anxiogenic effects. To address this issue, electrophysiological analyses were conducted to characterize dlBNST neurons projecting to the CeA, LH, and VTA. dlBNST neurons can be electrophysiologically classified into three distinct cell types (types IIII) according to their responses to depolarizing and hyperpolarizing current injections. Whole-cell patch-clamp recordings revealed that more than 60% of the CeA-projecting dlBNST neurons were type II, whereas approximately 80% of the LH- and VTA-projecting dlBNST neurons were type III. These electrophysiological results will help elucidate the mechanisms underlying the heterogeneity of BNST neurons during the regulation of anxiety-like behaviors.
机译：StriaSivalis（BNST）和中央氨基达拉（CEA）的床核包含已被描述为延长的杏仁醛的前脑单元。这两个核彼此发送密集的预测，并涉及对负面情绪状态的调节，包括焦虑和恐惧。本研究采用了致敏技术来检查CEA突出的背体BNST（DLBNST）神经元终端的刺激是否会影响雄性Sprague-Dawley大鼠的焦虑样行为。 CEA突出的DLBNST神经元末端的光刺激在升高的加迷宫试验中产生了焦虑作用。该发现与之前的报道不一致，表明将BNST神经元突出到外侧下丘脑（LH）和腹侧特子区域（VTA）产生抗焦虑而不是焦虑作用的结果。为了解决这个问题，进行电生理学分析以表征突出到CEA，LH和VTA的DLBNST神经元。 DLBNST神经元可以根据其对去极化和超极化电流注射的反应来电生理学上分为三种不同的细胞类型（类型IIII）。全细胞贴片夹具录制显示，超过60％的CEA突出的DLBNST神经元II型，而大约80％的LH-和VTA突出的DLBNST神经元是III型。这些电生理结果将有助于阐明在调节焦虑的行为期间BNST神经元的异质性下面的机制。

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