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首页> 外文期刊>The European Journal of Neuroscience >Enhanced oxidative stress contributes to worse prognosis and delayed neurofunctional recovery after striatal intracerebral hemorrhage in 5XFAD mice
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Enhanced oxidative stress contributes to worse prognosis and delayed neurofunctional recovery after striatal intracerebral hemorrhage in 5XFAD mice

机译：增强的氧化应激有助于在5xFAD小鼠中综合脑出血后的预后更差和延迟神经功能恢复

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Although Alzheimer's disease (AD) is associated with an increased risk of intracerebral hemorrhage (ICH) caused by hypertension and cerebral amyloid angiopathy, the precise clinical course after hypertensive ICH in AD patients is still unknown. In this study, we investigated how striatal ICH, a frequent site for hypertensive ICH, affected the prognosis of AD. We employed 17- and 18-month-old male 5XFAD (5X) mice and littermate (LT) controls, and striatal ICH was induced by collagenase injection. First, to address the acute effects of ICH on 5X mice, hemorrhagic volume and brain edema were evaluated 3 days after ICH. Next, to address the long-term effects of ICH on 5X mice, morbidity, mortality, neurological function (beam-walking and rotarod tests), and cognitive function (Y-maze and nest-building tests) were monitored. Twenty-eight days later, the animals were euthanized, their brains were isolated, and the cytotoxic alterations were investigated. The results revealed that the acute effects of ICH were not significantly different between 5X and LT mice. In contrast, 5X mice showed significantly higher morbidity and mortality in response to ICH, as well as delayed neurological function recovery, compared to LT mice through 28 days. ICH did not affect cognitive function in either group. Infiltrated macrophages in the perihemorrhagic cortex, gp91(phox), p67(phox), and COX-2 were significantly increased in 5X mice in response to ICH. We demonstrated that striatal ICH deteriorated prognosis and delayed neurofunctional recovery in 5X mice, which might be associated with enhanced oxidative stress in the presence of AD-like pathology.
机译：尽管阿尔茨海默病（Ad）与高血压和脑淀粉样血管病引起的脑内出血（ICH）的风险增加，但AD患者高血压患者后的精确临床过程仍然未知。在这项研究中，我们调查了高血压性ICH的频繁部位，影响了广告的预后。我们雇用了17岁和18个月的男性5xFAD（5倍）小鼠和凋落物（LT）对照，并通过胶原酶注射诱导纹状体ICH。首先，为了解决5X小鼠的ICH的急性效果，在ICH后3天评估出血量和脑水肿。接下来，为了解决5x小鼠，发病率，死亡率，神经功能（光束行走和滚石测试）和认知功能（Y型迷宫和巢式测试）的长期效应。二十八天后，将动物安乐死，分离出血管，并研究了细胞毒性改变。结果表明，在5倍和LT小鼠之间的急性效应没有显着差异。相比之下，与LT LT小鼠通过28天，5X小鼠表现出显着较高的发病率和死亡率，以及延迟神经功能恢复。 ICH在任一组中没有影响认知功能。在5倍的小鼠响应于ICH，在5X小鼠中渗透浸润巨噬细胞，GP91（PHOX），P67（PHOX）和COX-2显着增加。我们证明，5X小鼠中的预后和延迟神经官能回收的纹状体，这可能与增强的氧化应激存在于AD样病理情况下。

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