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首页> 外文期刊>The European Journal of Neuroscience >The ventrolateral periaqueductal grey updates fear via positive prediction error
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The ventrolateral periaqueductal grey updates fear via positive prediction error

机译：ventrolateral periaguctal灰色通过阳性预测误差更新恐惧

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摘要

Aversive, positive prediction error (+PE) provides a mechanism to update and increase future fear to uncertain threat predictors. The ventrolateral periaqueductal grey (vlPAG) has been offered as a neural locus for +PE computation. Yet, a causal demonstration of vlPAG +PE activity to update fear remains elusive. We devised a fear discrimination procedure in which a danger cue predicts shock deterministically and an uncertainty cue predicts shock probabilistically, requiring prediction errors to achieve an appropriate fear response. Recording vlPAG single-unit activity during fear discrimination in Long-Evans rats, we reveal activity related to shock is consistent with +PE and updates subsequent fear to uncertainty at the trial level. We further demonstrate that vlPAG inhibition during shock selectively decreases future fear to uncertainty, but not danger, and temporal emergence of this effect is consistent with single-unit activity. These findings provide causal evidence that vlPAG +PE is necessary for fear updating.
机译：厌恶的阳性预测误差（+ PE）提供了更新和增加未来对不确定威胁预测因子的恐惧的机制。腹外侧PeriaqueDuctal灰色（VLPAG）被提供为+ PE计算的神经基因座。然而，更新恐惧的VLPAG + PE活动的因果示范仍然难以捉摸。我们设计了一种恐惧歧视程序，其中危险提示预测了确定的休克，并且不确定性提示预测休克概率，需要预测误差以实现适当的恐惧响应。在长埃文斯大鼠的恐惧歧视期间记录VLPAG单位活动，我们揭示与休克相关的活动与+ PE符合+ PE，并更新随后对试验水平的不确定性的恐惧。我们进一步证明，在休克期间的VLPAG抑制选择性地降低了未来对不确定性的恐惧，但不危险，并且这种效果的时间出现与单一单位活动一致。这些发现提供了因果证据，即VLPAG + PE是必要的恐惧更新。

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