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首页> 外文期刊>The European Journal of Neuroscience >Corticosterone regulates both naturally occurring and cocaine‐induced dopamine signaling by selectively decreasing dopamine uptake
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Corticosterone regulates both naturally occurring and cocaine‐induced dopamine signaling by selectively decreasing dopamine uptake

机译：皮质酮通过选择性降低多巴胺摄取来调节天然存在的和可卡因诱导的多巴胺信号传导

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Abstract Stressful and aversive events promote maladaptive rewardseeking behaviors such as drug addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data from our laboratory and others show that stress and cocaine can interact to produce a synergistic effect on reward circuitry. This effect is also observed when the stress hormone corticosterone is administered directly into the nucleus accumbens (NA c), indicating that glucocorticoids act locally in dopamine terminal regions to enhance cocaine's effects on dopamine signaling. However, prior studies in behaving animals have not provided mechanistic insight. Using fastscan cyclic voltammetry, we examined the effect of systemic corticosterone on spontaneous dopamine release events (transients) in theNA c core and shell in behaving rats. A physiologically relevant systemic injection of corticosterone (2 g/kg i.p.) induced an increase in dopamine transient amplitude and duration (both voltammetric measures sensitive to decreases in dopamine clearance), but had no effect on the frequency of transient release events. This effect was compounded by cocaine (2.5 g/kg i.p.). However, a second experiment indicated that the same injection of corticosterone had no detectable effect on the dopaminergic encoding of a palatable natural reward (saccharin). Taken together, these results suggest that corticosterone interferes with naturally occurring dopamine uptake locally, and this effect is a critical determinant of dopamine concentration specifically inituations in which the dopamine transporter is pharmacologically blocked by cocaine.
机译：摘要压力和厌恶事件促进适用于培养的多巴胺系统的药物成瘾等不良奖励行为。使用动物模型，我们实验室和其他人的数据表明，压力和可卡因可以互动，以产生对奖励电路的协同影响。当将胁迫激素皮质酮直接施用于核常规（NA C）时，也观察到这种效果，表明糖皮质激素在多巴胺末端区域局部作用，以增强可卡因对多巴胺信号传导的影响。然而，在行为动物的事先研究没有提供机械洞察力。采用FastScan循环伏安法，我们检查了系统性皮质酮对Thena C核心和表现大鼠壳体中自发多巴胺释放事件（瞬态）的影响。生理上相关的皮质酮（2g / kg I.P.）的系统注射诱导多巴胺瞬态幅度和持续时间（对多巴胺间隙敏感的伏安措施敏感的持续时间），但对瞬态释放事件的频率没有影响。通过可卡因配混这种效果（2.5g / kg i.p.）。然而，第二个实验表明，同样的皮质酮注射对可口自然奖励（糖精）的多巴胺能编码没有可检测的影响。总之，这些结果表明皮质酮在局部干扰天然存在的多巴胺摄取，并且这种效果是多巴胺浓度的关键决定因子，特别是通过可卡因药理学封闭的多巴胺浓度。

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    Wheeler Daniel S.; Ebben Amanda L.; Kurtoglu Beliz; Lovell Marissa E.; Bohn Austin T.; Jasek Isabella A.; Baker David A.; Mantsch John R.; Gasser Paul J.; Wheeler Robert A.;

  • 作者单位

    Department of Biomedical SciencesMarquette University560?N. 16th St SC 446 Milwaukee WI 53233 USA;

    Department of Biomedical SciencesMarquette University560?N. 16th St SC 446 Milwaukee WI 53233 USA;

    Department of Biomedical SciencesMarquette University560?N. 16th St SC 446 Milwaukee WI 53233 USA;

    Department of Biomedical SciencesMarquette University560?N. 16th St SC 446 Milwaukee WI 53233 USA;

    Department of Biomedical SciencesMarquette University560?N. 16th St SC 446 Milwaukee WI 53233 USA;

    Department of Biomedical SciencesMarquette University560?N. 16th St SC 446 Milwaukee WI 53233 USA;

    Department of Biomedical SciencesMarquette University560?N. 16th St SC 446 Milwaukee WI 53233 USA;

    Department of Biomedical SciencesMarquette University560?N. 16th St SC 446 Milwaukee WI 53233 USA;

    Department of Biomedical SciencesMarquette University560?N. 16th St SC 446 Milwaukee WI 53233 USA;

    Department of Biomedical SciencesMarquette University560?N. 16th St SC 446 Milwaukee WI 53233 USA;

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  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    cocaine; corticosterone; dopamine; stress; voltammetry;

    机译：可卡因;皮质酮;多巴胺;压力;伏安法;

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