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首页> 外文期刊>The European Journal of Neuroscience >Differential and complementary roles of medial and lateral septum in the orchestration of limbic oscillations and signal integration
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Differential and complementary roles of medial and lateral septum in the orchestration of limbic oscillations and signal integration

机译：内侧和侧面隔膜在林振荡弦中的差异和互补作用及信号集成

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Abstract Anatomical differences between the medial and lateral septum have associated these nuclei with dissimilar functional roles and behaviours. While the medial septum has been implicated, predominantly, in theta rhythm generation along the septo‐hippocampal axis, the lateral septum has mainly been investigated in the context of septo‐hypothalamic dialogue. Recent advances suggest that medial and lateral septum are more closely functionally related than previously appreciated. Here, we explore the hypothesis that the medial septum mediates ascending septo‐hippocampal theta propagation, while the lateral septum processes a descending hippocampo‐septal and septo‐hypothalamic reinforcement signal that mediates navigation during motivated behaviour. The generation and propagation of theta rhythm are critical for the initiation of exploratory behaviour. Indeed, theta signal processing of medial and lateral septum nuclei may well be involved in the integration of spatial, rewarding and locomotor signals across different brain networks. We review here the structural features, anatomical connectivity and functional properties of the medial and lateral septum. We discuss the heterogeneous anatomy of the lateral septum, which is composed of diverse subregions with distinct ascending and descending projections, and we relate the physiological characteristics of septal nuclei to their functional relationships with the hippocampal formation, the hypothalamus and the brainstem reticular formation during motivated spatial navigation.
机译：摘要内侧和侧面隔膜之间的解剖学差异具有与不同的功能作用和行为相关的这些核。虽然内侧隔膜主要涉及沿着散发海马轴的θ节奏，但在隔水缺失对话的背景下主要研究了外侧隔膜。最近的进展表明，内侧和侧面隔膜比以前欣赏更密切相关。在这里，我们探讨了内侧隔膜介导上升侧面海马θ传播的假设，而横向隔膜处理下降的海马 - 中下丘脑增强信号，介导在激励行为期间导航。 θthythm的产生和传播对于启动探索性行为至关重要。实际上，内侧和侧面隔膜核的θ信号处理可能很好地参与在不同脑网络上的空间，奖励和运动信号的整合。我们在此审查内侧和外侧隔膜的结构特征，解剖学连接和功能性质。我们讨论了侧面隔膜的异质解剖学，其由具有不同上升和下降突出的各种子区域组成，并且我们将隔膜核与海马形成，下丘脑和脑干网状形成期间的功能关系的生理特征涉及激励空间导航。

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