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首页> 外文期刊>The European Journal of Neuroscience >Dopamine modulates the optomotor response to unreliable visual stimuli in Drosophila melanogaster
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Dopamine modulates the optomotor response to unreliable visual stimuli in Drosophila melanogaster

机译：多巴胺调节果蝇对果蝇的不可靠的视觉刺激的反应

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State-dependent modulation of sensory systems has been studied in many organisms and is possibly mediated through neuromodulators such as monoamine neurotransmitters. Among these, dopamine is involved in many aspects of animal behaviour, including movement control, attention, motivation and cognition. However, the precise neural mechanism underlying dopaminergic modulation of behaviour induced by sensory stimuli remains poorly understood. Here, we used Drosophila melanogaster to show that dopamine can modulate the optomotor response to moving visual stimuli including noise. The optomotor response is the head-turning response to moving objects, which is observed in most sight-reliant animals including mammals and insects. First, the effects of the dopamine system on the optomotor response were investigated in mutant flies deficient in dopamine receptors D1R1 or D1R2, which are involved in the modulation of sleep-arousal in flies. We examined the optomotor response in D1R1 knockout (D1R1 KO) and D1R2 knockout (D1R2 KO) flies and found that it was not affected in D1R1 KO flies; however, it was significantly reduced in D1R2 KO flies compared with the wild type. Using cell-type-specific expression of an RNA interference construct of D1R2, we identified the fan-shaped body, a part of the central complex, responsible for dopamine-mediated modulation of the optomotor response. In particular, pontine cells in the fan-shaped body seemed important in the modulation of the optomotor response, and their neural activity was required for the optomotor response. These results suggest a novel role of the central complex in the modulation of a behaviour based on the processing of sensory stimulations.
机译：在许多生物中研究了对感官系统的状态依赖性调制，并且可能通过诸如单胺神经递质的神经调节剂介导。其中，多巴胺涉及动物行为的许多方面，包括运动控制，关注，动机和认知。然而，受感觉刺激诱导的行为的多巴胺能调节的精确神经机制仍然难以理解。在这里，我们使用了果蝇黑素转垫，表明多巴胺可以调节亮光响应，以实现包括噪声的视觉刺激。亮光响应是对移动物体的头部转向响应，在包括哺乳动物和昆虫的大多数视力依赖性动物中观察到。首先，在多巴胺受体D1R1或D1R2缺乏缺陷的突变蝇中研究了多巴胺系统对亮光反应的影响，该突变体受体D1R1或D1R2缺乏，其参与苍蝇的睡眠唤醒的调节。我们检查了D1R1敲除（D1R1 KO）和D1R2敲除（D1R2 KO）苍蝇中的亮光响应，发现它不受D1R1 KO苍蝇的影响;然而，与野生型相比，D1R2 KO苍蝇显着降低。使用D1R2的RNA干扰构建体的细胞型特异性表达，我们鉴定了扇形体，中央复合物的一部分，负责多巴胺介导的亮光响应的调节。特别地，扇形主体中的卵氏细胞在调节亮光响应的调节方面似乎是重要的，并且它们的神经活性是对洋光运动反应所需的。这些结果表明中央综合体在基于感觉刺激加工的行为调制中的新的作用。

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