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首页> 外文期刊>The European Journal of Neuroscience >Insulin in the ventral tegmental area reduces cocaine-evoked dopamine in the nucleus accumbens in vivo
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Insulin in the ventral tegmental area reduces cocaine-evoked dopamine in the nucleus accumbens in vivo

机译：腹侧胰岛素在腹侧引起的区域减少了在体内核心宫内的可卡因诱发的多巴胺

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摘要

Mesolimbic dopamine circuits, implicated in incentive motivation, are sensitive to changes in metabolic state such as weight loss and diet-induced obesity. These neurons are important targets for metabolic hormones such as leptin, glucagon-like peptide-1, ghrelin and insulin. Insulin receptors are located on dopamine neurons in the ventral tegmental area (VTA) and we have previously demonstrated that insulin induces long-term depression of excitatory synapses onto VTA dopamine neurons. While insulin can decrease dopamine concentration in somatodendritic regions, it can increase dopamine in striatal slices. Whether insulin directly targets the VTA to alter dopamine release in projection areas, such as the nucleus accumbens (NAc), remains unknown. The main goal of the present experiments was to examine NAc dopamine concentration following VTA administration of insulin. Using in vivo FSCV to detect rapid fluctuations in dopamine concentration, we showed that intra-VTA insulin via action at insulin receptors reduced pedunculopontine nucleus-evoked dopamine release in the NAc. Furthermore, intra-VTA insulin reduced cocaine-potentiated NAc dopamine. Finally, intra-VTA or intranasal insulin decreased locomotor responses to cocaine, an effect blocked by an intra-VTA administered insulin receptor antagonist. Together, these data demonstrate that mesolimbic dopaminergic projections are important targets of the metabolic hormone, insulin.
机译：培养的多巴胺电路涉及激励动机，对代谢状态的变化敏感，例如减肥和饮食诱导的肥胖症。这些神经元是瘦素，胰高血糖素肽-1，Ghrelin和胰岛素等代谢激素的重要靶标。胰岛素受体位于腹侧三胺区域（VTA）的多巴胺神经元上，我们以前证明胰岛素诱导兴奋性突触的长期抑制在VTA多巴胺神经元上。虽然胰岛素可以降低躯体素浓度的躯体浓度，但它可以在纹状体切片中增加多巴胺。胰岛素是否直接靶向VTA以改变投影区域中的多巴胺释放，例如核常规（NAC），仍然未知。本实验的主要目的是检查VTA胰岛素施用后的NAC多巴胺浓度。使用体内FSCV检测多巴胺浓度的快速波动，我们展示了VTA内胰岛素通过在胰岛素受体中的作用减少了Pedintulopontine诱发的多巴胺释放在NaC中。此外，VTA内胰岛素还原可卡因增强的NAc多巴胺。最后，VTA内或鼻内胰岛素降低了对可卡因的运动反应，由VTA内置于VTA incleratered胰岛素受体拮抗剂的效果。这些数据在一起表明，培素咪啶多巴胺能突起是代谢激素，胰岛素的重要靶标。

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