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首页> 外文期刊>The European Journal of Neuroscience >Defining a multimodal signature of remote sports concussions
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Defining a multimodal signature of remote sports concussions

机译:定义远程运动脑震荡的多模式签名

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Sports-related concussions lead to persistent anomalies of the brain structure and function that interact with the effects of normal ageing. Although post-mortem investigations have proposed a bio-signature of remote concussions, there is still no clear invivo signature. In the current study, we characterized white matter integrity in retired athletes with a history of remote concussions by conducting a full-brain, diffusion-based connectivity analysis. Next, we combined MRI diffusion markers with MR spectroscopic, MRI volumetric, neurobehavioral and genetic markers to identify a multidimensional invivo signature of remote concussions. Machine learning classifiers trained to detect remote concussions using this signature achieved detection accuracies up to 90% (sensitivity: 93%, specificity: 87%). These automated classifiers identified white matter integrity as the hallmark of remote concussions and could provide, following further validation, a preliminary unbiased detection tool to help medical and legal experts rule out concussion history in patients presenting or complaining about late-life abnormal cognitive decline.
机译:与竞争相关的脑震荡导致脑结构持续的异常,与正常老化的影响相互作用。虽然验尸调查提出了远程脑震荡的生物签名,但仍然没有明确的Invivo签名。在目前的研究中,我们通过进行全脑,基于扩散的连接分析,以远程脑震荡的历史为历史上的白质诚信。接下来,我们将MRI扩散标志物与MR光谱,MRI体积,神经兽性和遗传标记组合,以确定远程脑震荡的多维因素签名。机器学习分类器接受培训以使用此签名检测远程脑震荡,实现高达90%的检测精度(灵敏度:93%,特异性:87%)。这些自动分类器确定了白质诚信作为远程脑震荡的标志,可以在进一步验证之后提供初步无偏见的检测工具,以帮助医疗和法律专家排除患者的脑震荡历史,呈现或抱怨晚期异常认知下降。

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